Simple and effective method for the synthesis of 3′,5′-substituted 1-β-D-arabinofuranosyluracil

Article abstract of DOI:10.1007/BF01165730

3′,5′-Substituted arabinofuranosyluracil is a starting compound in 2′-modifications. A convenient and effective method is proposed for the synthesis of 1-(3′,5′-di-o-trityl-β-D-arabinofuranosyl)uracil by successive reactions of 2,2′-cyclization of uridine, 3′,5′-tritylation of the 2,2′-anhydrouridine, and hydrolytic cleavage of the 2,2′-anhydro bond. 1997 Plenum Publishing Corporation.