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Product FOB Price Min.Order Supply Ability Supplier
N,N-Diethyl-3-methylbenzamide
Cas No: 134-62-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
DEET
Cas No: 134-62-3
No Data No Data 3 Metric Ton/Day Skyrun Industrial Co.,Ltd Contact Supplier
CAS 134-62-3 N,N-Diethyl-3-methylbenzamide
Cas No: 134-62-3
USD $ 1.0-2.0 / Gram 10 Gram 12 Kilogram/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier
N,N-Diethyl-3-methylbenzamide/DEET
Cas No: 134-62-3
No Data 1 Metric Ton 1000 Metric Ton/Day Hefei TNJ chemical industry co.,ltd Contact Supplier
Top quality 99.5%Deet
Cas No: 134-62-3
No Data 500 Kilogram 1.2 Metric Ton/Day Hunan Xuetian Fine Chemical Industry Co,.Ltd Contact Supplier
High quality N,N-Diethyl-m-toluamide supplier in China
Cas No: 134-62-3
No Data 1 Kilogram 5000 Metric Ton/Year Simagchem Corporation Contact Supplier
High purity 134-62-3 N,N-Diethyl-3-methylbenzamide
Cas No: 134-62-3
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
N,N-Diethyl-3-methylbenzamide CAS NO.134-62-3
Cas No: 134-62-3
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
N,N-Diethyl-m-toluamide CAS 134-62-3
Cas No: 134-62-3
USD $ 20.0-23.8 / Kilogram 25 Kilogram 10000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
huge stock TC Insecticide N,N-Diethyl-m-toluamide 134-62-3 GLP Manufacturer
Cas No: 134-62-3
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

134-62-3 Usage

Chemical Properties

Pale yellow liquid. There are light citrus fragrance smell.

Insect repellent effects of various products

The product containing chemical drug N,N-Diethyl-3-methylbenzamide owns best effects. Preferably, the time it can provide protection is proportional to the concentration of N,N-Diethyl-3-methylbenzamide products. For using products with N,N-Diethyl-3-methylbenzamide concentration at 23.8%, 20%, 6.6% and 4.8% , the protection times of the participants for the first time the average time being bitten are 302 minutes, 234 minutes, 112 minutes, 88 minutes, respectively . The average time of plant protection products as follows: 2% soybean oil products for 95 minutes; citronella oil product containing different concentrations of 3 to 20 minutes; the average protection time containing eucalyptus oil repellent latest listing of 120 minute. Many consumers believe that there is repellent function of the "Skin Bath Oil", provide protection only 10 minutes. Products contains a chemical component (Merck insecticide product IR3535) , the average protection time is only 23 minutes.

Air & Water Reactions

N,N-Diethyl-3-methylbenzamide is sensitive to prolonged exposure to moisture. Insoluble in water.

Uses

Insect repellent

Chemical Properties

Colorless to Amberlike Liquid

Pregnant women should us N,N-Diethyl-3-methylbenzamide insect repellents with caution

N,N-Diethyl-3-methylbenzamide has potential risks to humans, especially pregnant women: after contacted with the skin, N,N-Diethyl-3-methylbenzamide-containing insect repellent products will penetrate into the blood, it is possible through the blood into the placenta, even umbilical cord, which may result in teratogenic. Pregnant women should avoid using N,N-Diethyl-3-methylbenzamide containing insect repellent products, pregnant women can choose to wear light-colored long-sleeved shirt and trousers, or using products containing natural ingredients repellent to prevent mosquito bites. If necessary, using insect repellent containing N,N-Diethyl-3-methylbenzamide products should also be with the lowest concentration and effective insect repellent components as possible.

Indications

DEET is an organic liquid that is an excellent mosquito repellent; stronger preparations of DEET are also effective against stable flies, although little protection is provided against ticks. Commercial preparations are available in aerosol, cream, or lotion form and vary in concentration from 6% to 100%. Because DEET is absorbed into the bloodstream, it should be applied sparingly. Lesser concentrations of DEET should be used whenever possible, with additional applications to the skin if needed. Reports of a toxic encephalopathy and brief seizures have been documented in children after overzealous use. Less serious neurologic side effects include confusion, irritability, and insomnia. Contact dermatitis has been observed with preparations containing higher concentrations of DEET. Use preparations with <20% DEET in children. Avoid mucous membranes, broken skin, and hands of children, because they are often in contact with the mouth. Spray clothing instead of skin whenever possible, but avoid contact with rayon, acetate, or spandex, because these materials may be damaged by DEET.

Uses

1. As major components for a variety of solid, liquid mosquito repellent series. 2. Insect repellent, having unique effects for mosquito controlling . Formulation: 70%, 95% liquid.

Outline

N,N-Diethyl-3-methylbenzamide, with the chemical name diethyl toluamide, is a broad-spectrum insect repellent, having repellent effect upon a variety of biting insects in various environments , can be used to drive thorn flies, midges, black flies, chiggers, deer flies, fleas, gnats, horse flies, mosquitoes, sand flies, gnats, flies and stable flat lice. N,N-Diethyl-3-methylbenzamide is a development by the US Department of Agriculture during the World War II and has the patent, the product is designated as a repellent products for the use in the US Army in 1946. In 1957 the United States Environmental Protection Agency started civil application as an insect repellent registration, initially as a pesticide on the farm, and later the United States Government applied for its use in times of war, especially war in Vietnam and Southeast Asia, the United States Environmental Protection Agency statistics, every year nearly 40 percent of Americans use N,N-Diethyl-3-methylbenzamide-containing insect repellent, there are about 200 million people worldwide usage for over 40 years by more than 20,000 units of the research studies prove that N,N-Diethyl-3-methylbenzamide is the most secure and effective broad-spectrum repellent. World Health Organization has recommended the use of repellent products containing N,N-Diethyl-3-methylbenzamide to protect against insect vectors. Often mixed with other pesticides, but when it is mixed with an amino acid salts, pesticides toxicity will increase.

Fire Hazard

N,N-Diethyl-3-methylbenzamide is combustible.

Uses

insect repellant

production method

By the Inter-toluene chloride and diethyl amine reaction. Industrial products containing 5%-15% isomer.

Definition

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. It is the most widely used insect repellent worldwide.

History

Formulations registered for direct human application contain from 4% to 100% DEET. DEET was developed as a joint effort by the Department of Defense and U.S. Department of Agriculture (USDA). After examining hundreds of compounds for their repellent capabilities in the 1940s, DEET was selected and patented by the U.S. Army in 1946.the USDA did not announce DEET’s discovery until 1954, and it was registered for public use in 1957. DEET is prepared from m-toluoyl chloride and diethylamine in benzene or ether.

Reactivity Profile

N,N-Diethyl-3-methylbenzamide is incompatible with strong acids, strong bases and strong oxidizing agents. N,N-Diethyl-3-methylbenzamide hydrolyzes slowly in the presence of water. N,N-Diethyl-3-methylbenzamide has a solvent effect on most plastics, paints, and varnishes. N,N-Diethyl-3-methylbenzamide is also incompatible with rayon, acetate or dynel clothing.

US Morflex one-step synthesis

US Morflex founded in 1927, located in Greensboro, United States, is the world's largest manufacturer of N,N-Diethyl-3-methylbenzamide . It owns 40 years of production and sales of N,N-Diethyl-3-methylbenzamide history, providing 60 percent of global consumption. Users include Johnson, Bayer and other famous enterprises, Morflex repellent cream formulation has cosmetic properties, non-irritating to human skin, more even applied than alcohol formula , more comfortable, no dry and tight and not greasy sense after the use of alcohol formula, specially formulated to lock N,N-Diethyl-3-methylbenzamide in sweat, friction, etc., can maintain long-lasting efficacy. Its production methods can be called "one step synthesis" , the advantage of "one step synthesis" is that it does not produce chemical synthesis additions-phosphoric acid, hydrochloric acid, amine hydrochloride or benzene. Phosphoric acid can cause greasy products, and other impurities are either irritating to the skin, or harmful to the human body. The multi-step synthesis methods currently used in the country can not avoid these harmful chemicals addenda. The above information is edited by the Chemicalbook of Tian Ye.

General Description

Clear colorless or faintly yellow slightly viscous liquid. Faint pleasant odor.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and skin contact. Human systemic effects: coma, convulsions, dermatitis, mydriasis @upillary ddation), nausea or vomiting, stiffness. An eye and skin irritant. Experimental reproductive effects by skin contact. Mutation data reported. Can cause central nervous system disturbances. A pesticide. DEET is the active ingredient in most commercial insect repellents. When heated to decomposition it emits toxic fumes of NOx
InChI:InChI=1/C12H17NO/c1-4-9-6-7-11(12(13)14)10(5-2)8(9)3/h6-7H,4-5H2,1-3H3,(H2,13,14)

134-62-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 100g 223.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 500g 461.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 2500g 1958.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 100g 223.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 500g 461.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 2500g 1958.0CNY Detail
USP (1197007)  Diethyltoluamide  United States Pharmacopeia (USP) Reference Standard 134-62-3 1197007-3G 4,326.66CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 100g 223.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 500g 461.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 2500g 1958.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 100g 223.0CNY Detail
Alfa Aesar (A17486)  N,N-Diethyl-3-methylbenzamide, 97%    134-62-3 500g 461.0CNY Detail

134-62-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-diethyl-m-toluamide

1.2 Other means of identification

Product number -
Other names Diethyltoluamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Halogenated pesticides and related compounds
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134-62-3 SDS

134-62-3Synthetic route

diethylamine
109-89-7

diethylamine

3-Methylbenzoyl chloride
1711-06-4

3-Methylbenzoyl chloride

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With sodium hydroxide In water at 45℃; for 0.05h; Temperature; Reagent/catalyst;97.5%
With benzene
With triethylamine Heating; Microwave irradiation;
With triethylamine In dichloromethane at 0 - 20℃;
at 0 - 20℃; for 20h; Alkaline conditions;
N,N-diethylcarbamyl chloride
88-10-8

N,N-diethylcarbamyl chloride

m-Toluic acid
99-04-7

m-Toluic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With triethylamine at 20℃; for 0.333333h;97.5%
With triethylamine at 20℃; for 0.333333h;97.5%
diethylamine
109-89-7

diethylamine

m-Toluic acid
99-04-7

m-Toluic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With Zn-MCM-22 catalyst at 100 - 280℃; under 15001.5 Torr; for 6h; Inert atmosphere; Large scale;96%
Stage #1: m-Toluic acid With niobium pentachloride In dichloromethane
Stage #2: diethylamine In dichloromethane at 45 - 50℃; for 2.5h;
85%
hydroxy-apatite at 280 - 320℃; Product distribution; other catalysts; var. reaction time and temp.; influence of mineral acids with different pKa values;
N-formyldiethylamine
617-84-5

N-formyldiethylamine

m-Toluic acid
99-04-7

m-Toluic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In 1,4-dioxane at 120℃; for 22h;91%
3-Methylbenzonitrile
620-22-4

3-Methylbenzonitrile

diethylamine
109-89-7

diethylamine

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Stage #1: diethylamine With ethylmagnesium bromide In tetrahydrofuran; diethyl ether at 30℃; for 1h;
Stage #2: 3-Methylbenzonitrile With ethylmagnesium bromide In diethyl ether; dichloromethane at 30℃; for 1h;
Stage #3: With hydrogenchloride In tetrahydrofuran; diethyl ether; dichloromethane at 22℃;
90%
3-Methylbenzotrichloride
3335-34-0

3-Methylbenzotrichloride

triethylamine
121-44-8

triethylamine

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With heptamethyl Coβ-perchlorato-cob(II)yrinate; tetrabutylammonium perchlorate In acetonitrile at 20℃; for 3h; Electrolysis;90%
carbon monoxide
201230-82-2

carbon monoxide

3-Iodotoluene
625-95-6

3-Iodotoluene

diethylamine
109-89-7

diethylamine

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With palladium diacetate; triethylamine; triphenylphosphine In toluene at 80℃; for 18h; Sealed tube;89%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; under 750.075 Torr; for 2h; Autoclave; chemoselective reaction;85%
With triethylamine In N,N-dimethyl acetamide at 130℃; under 15001.5 Torr; for 1.5h; Autoclave; Green chemistry;84%
triethylamine
121-44-8

triethylamine

m-Toluic acid
99-04-7

m-Toluic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With trifuran-2-yl-phosphane; palladium diacetate; 2,2-dimethylpropanoic anhydride In toluene at 120℃; for 15h; Inert atmosphere;89%
m-toluic acid diethylammonium salt

m-toluic acid diethylammonium salt

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
at 200℃; for 0.0277778h; Product distribution / selectivity; microwave irradiation;88%
potassium trifluoro(3-methylphenyl)borate

potassium trifluoro(3-methylphenyl)borate

2-(diethylamino)-2-oxoacetic acid
55441-26-4

2-(diethylamino)-2-oxoacetic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With dipotassium peroxodisulfate; palladium diacetate In water; dimethyl sulfoxide; acetonitrile at 20℃;86%
m-toluic acid diethylammonium salt

m-toluic acid diethylammonium salt

A

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

B

N-ethyl-m-Toluamide
26819-07-8

N-ethyl-m-Toluamide

Conditions
ConditionsYield
With tetrabutoxytitanium at 200℃; under 15001.5 Torr; for 0.0333333h; Product distribution / selectivity; microwave irradiation;A 81%
B 9%
furfural
98-01-1

furfural

3-Iodotoluene
625-95-6

3-Iodotoluene

triethylamine
121-44-8

triethylamine

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With Wilkinson’s catalyst; 1,3-bis-(diphenylphosphino)propane; water In tetrahydrofuran at 140℃; for 12h; Inert atmosphere; Sealed tube;80%
diethyl amine hydrochloride
660-68-4

diethyl amine hydrochloride

m-Toluic acid
99-04-7

m-Toluic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With silica gel; triethylamine; p-toluenesulfonyl chloride at 20℃; for 0.0166667h;76%
With triethylamine at 20℃; for 0.0166667h;60%
1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
4064-06-6

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine
500131-50-0

N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine

A

6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-D-galctopyranose
2021-97-8, 6185-32-6, 70981-54-3

6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-D-galctopyranose

B

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
In n-heptane for 0.333333h; microwave irradiation;A 70%
B n/a
isopropyl 2-(diethylcarbamoyl)-4-methylbenzoate

isopropyl 2-(diethylcarbamoyl)-4-methylbenzoate

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate In toluene at 20 - 180℃; for 14h; Inert atmosphere; Glovebox; Sealed tube;64%
N,N-Diethyl-3-methyl-2-(2-methyl-propane-2-sulfonyl)-benzamide
118354-88-4

N,N-Diethyl-3-methyl-2-(2-methyl-propane-2-sulfonyl)-benzamide

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
With hydrogen; nickel In ethanol for 15h; Heating;55%
tert-butyl phenyl sulfide
3019-19-0

tert-butyl phenyl sulfide

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2O2 / acetic acid / 3 h / 100 °C
2: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h, 2.) -78 deg C
3: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C
4: 55 percent / H2 / Raney Ni / ethanol / 15 h / Heating
View Scheme
tert-butyl-phenyl sulfone
4170-72-3

tert-butyl-phenyl sulfone

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h, 2.) -78 deg C
2: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C
3: 55 percent / H2 / Raney Ni / ethanol / 15 h / Heating
View Scheme
2-<(1,1-dimethylethyl)sulphonyl>-N,N'-diethylbenzamide
118335-04-9

2-<(1,1-dimethylethyl)sulphonyl>-N,N'-diethylbenzamide

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C
2: 55 percent / H2 / Raney Ni / ethanol / 15 h / Heating
View Scheme
phenyllithium
591-51-5

phenyllithium

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / -78 °C
2: H2O2 / acetic acid / 3 h / 100 °C
3: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h, 2.) -78 deg C
4: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C
5: 55 percent / H2 / Raney Ni / ethanol / 15 h / Heating
View Scheme
diethylamine
109-89-7

diethylamine

m-toluic acid n-butyl ester

m-toluic acid n-butyl ester

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
sodium ethanolate at 305℃; under 26252.6 Torr; for 0.00944444h; autoclave; Industry scale; Microwave irradiation;
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

thionyl chloride
7719-09-7

thionyl chloride

dichloromethane
75-09-2

dichloromethane

dibenzylamine
103-49-1

dibenzylamine

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Stage #1: ortho-methylbenzoic acid; thionyl chloride; dichloromethane With N,N-dimethyl-formamide for 2h; Reflux;
Stage #2: dibenzylamine at 20℃;
diethylamine
109-89-7

diethylamine

3-(3-methylbenzoyl)-5,5-dimethylhydantoin

3-(3-methylbenzoyl)-5,5-dimethylhydantoin

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
In ethyl acetate at 50℃; Sealed tube;
3-methylbenzyl alcohol
587-03-1

3-methylbenzyl alcohol

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate; iron(III) chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 35 °C
2: ethyl acetate / 50 °C / Sealed tube
View Scheme
m-Toluic acid
99-04-7

m-Toluic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,3,5-trichloro-2,4,6-triazine; 1-pyrrolidinecarboxaldehyde / acetonitrile / Heating
2: 20 h / 0 - 20 °C / Alkaline conditions
View Scheme
2-bromo-5-methylbenzoic acid
6967-82-4

2-bromo-5-methylbenzoic acid

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 0 - 20 °C
1.2: 0 - 20 °C
2.1: zinc(II) chloride; diisobutylaluminium hydride; magnesium; lithium chloride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
2.2: 50 °C / Inert atmosphere
3.1: bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate / toluene / 14 h / 20 - 180 °C / Inert atmosphere; Glovebox; Sealed tube
View Scheme
2-bromo-N,N-diethyl-5-methylbenzamide

2-bromo-N,N-diethyl-5-methylbenzamide

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: zinc(II) chloride; diisobutylaluminium hydride; magnesium; lithium chloride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
1.2: 50 °C / Inert atmosphere
2.1: bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate / toluene / 14 h / 20 - 180 °C / Inert atmosphere; Glovebox; Sealed tube
View Scheme
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

N-ethyl-N-(3-methylbenzyl)ethanamine
22704-60-5

N-ethyl-N-(3-methylbenzyl)ethanamine

Conditions
ConditionsYield
With n-butyllithium; borane-THF; diisopropylamine at 25℃;99%
With lithium (diisopropylamino)borohydride In tetrahydrofuran at 25℃; for 2h;99%
With diisobutylaluminum borohydride In tetrahydrofuran at 0 - 25℃; Inert atmosphere;99%
styrene
292638-84-7

styrene

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

N,N-diethyl-5-methyl-2-(1-phenylethyl)benzamide
1620210-49-2

N,N-diethyl-5-methyl-2-(1-phenylethyl)benzamide

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; 1,4-bis[bis(pentafluorophenyl)phosphino]butane In 1,4-dioxane at 100℃; for 48h; Sealed tube; Inert atmosphere;99%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

N,N-diethyl-αlpha;-chloro-meta-toluylamidinum chloride
500131-49-7

N,N-diethyl-αlpha;-chloro-meta-toluylamidinum chloride

Conditions
ConditionsYield
With oxalyl dichloride In tetrachloromethane at 0 - 50℃; for 1.5h;98%
With oxalyl dichloride In tetrachloromethane at 0 - 50℃; for 1.5h;98%
With oxalyl dichloride In tetrachloromethane at 0 - 50℃; for 1.5h;
With oxalyl dichloride In tetrachloromethane at 0 - 50℃; for 1.5h;
1,1,1,3,5,5,5-heptamethyltrisiloxan
1873-88-7

1,1,1,3,5,5,5-heptamethyltrisiloxan

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

C19H37NO3Si3
1583285-82-8

C19H37NO3Si3

Conditions
ConditionsYield
With [Rh(coe)2OH]2; 3,4,5-MeO-MeO-BIPHEP; cyclohexene In tetrahydrofuran at 45℃; regioselective reaction;96%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 2.9-dimethyl-1,10-phenanthroline In 1,4-dioxane at 100℃; for 20h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Sealed tube; regioselective reaction;63%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

3-methylbenzyl alcohol
587-03-1

3-methylbenzyl alcohol

Conditions
ConditionsYield
With pyrrolidine; n-butyllithium; borane-THF at 25℃;95%
With LiPyrrBH3 In tetrahydrofuran at 25℃; for 2h;95%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

N,N-diethyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

N,N-diethyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 80℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;95%
Stage #1: bis(pinacol)diborane With C24H28ClIrN2O In n-heptane; isopropyl alcohol at 75℃; for 1h; Sealed tube; Inert atmosphere;
Stage #2: N,N-Diethyl-3-methylbenzamide In n-heptane; isopropyl alcohol Sealed tube; Inert atmosphere;
87%
Stage #1: bis(pinacol)diborane With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2’-bipyridine In hexane at 60℃; for 0.5h; Inert atmosphere; Glovebox; Sealed tube;
Stage #2: N,N-Diethyl-3-methylbenzamide With bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum In hexane at 20℃; for 18h; Sealed tube;
55%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

N,N-diethyl-3-methylthiobenzamide
1017241-61-0

N,N-diethyl-3-methylthiobenzamide

Conditions
ConditionsYield
With triethylamine; trichlorophosphate In water at 60 - 70℃; for 0.0833333h; microwave irradiation;89%
With trichlorothiophosphine; water; triethylamine Microwave irradiation;89%
With trichlorothiophosphine; water; triethylamine Heating; Microwave irradiation;
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

C24H30LaN3

C24H30LaN3

(4-(dimethylamino)phenyl)(m-tolyl)methanone
26704-95-0

(4-(dimethylamino)phenyl)(m-tolyl)methanone

Conditions
ConditionsYield
at 0℃; for 1h; Inert atmosphere; Schlenk technique;86%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine
500131-50-0

N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine

Conditions
ConditionsYield
Stage #1: N,N-Diethyl-3-methylbenzamide With oxalyl dichloride In dichloromethane at 40℃; for 2h;
Stage #2: With triethylamine tris(hydrogen fluoride); triethylamine In dichloromethane at 20℃; for 2h;
82%
Stage #1: N,N-Diethyl-3-methylbenzamide With oxalyl dichloride In dichloromethane at 40℃; for 2h;
Stage #2: With triethylamine tris(hydrogen fluoride); triethylamine In dichloromethane at 20℃; for 2h; Further stages.;
82%
With Carbonyl fluoride In 1,2-dichloro-ethane at 158℃; for 10h; Product distribution / selectivity;60%
With Carbonyl fluoride at 72 - 170℃; for 10h; Product distribution / selectivity;7%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

1-((5-phenylpent-1-en-2-yl)oxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide

1-((5-phenylpent-1-en-2-yl)oxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide

2-oxo-5-phenylpentyl 3-methylbenzoate

2-oxo-5-phenylpentyl 3-methylbenzoate

Conditions
ConditionsYield
With water In dichloromethane at 45℃; for 6h;82%
With water at 60℃; for 18h;82%
ethanol
64-17-5

ethanol

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

ethyl 3-methylbenzoate
120-33-2

ethyl 3-methylbenzoate

Conditions
ConditionsYield
With hydrogenchloride; iron(III) chloride hexahydrate In hexane; water at 80℃; for 14h;81%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

m-Toluic acid
99-04-7

m-Toluic acid

Conditions
ConditionsYield
With niobium(V) oxide; water In neat (no solvent) for 24h; Reflux; Inert atmosphere;76%
2,3-dimethyl-2,3-butane diol
76-09-5

2,3-dimethyl-2,3-butane diol

Trimethyl borate
121-43-7

Trimethyl borate

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

pinacolo[2-(N,N-diethylcarboxamido)-4-methylphenyl]boronate
698376-34-0

pinacolo[2-(N,N-diethylcarboxamido)-4-methylphenyl]boronate

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran (Ar); soln. of benzamide in THF was added dropwise to stirred soln. of s-BuLi/tetramethylethylenediamine (1/1) in THF at -78°C; mixt. wasstirred at -78°C for 1 h; treated with B(OMe)3; mixt. was warmed to room temp. over 8-12 h; quenched with satd. aq. NH4Cl; aq. phase extd. (Et2O); extract dried (Na2SO4); concd. (vac.); chromd. (silica gel, EtOAc/hexane); stirred with pinacol and MgSO4 in CH2Cl2 for 12 h; filtered; concd.; chromd. (silica gel, EtOAc/hexane, 1/3);70%
N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

A

3-methylbenzyl alcohol
587-03-1

3-methylbenzyl alcohol

B

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

Conditions
ConditionsYield
With titanium(IV) isopropylate; 1,1,3,3-Tetramethyldisiloxane In methyl cyclohexane at 20℃; for 15h; Inert atmosphere;A Ca. 10 %Spectr.
B 70%
Triethoxyvinylsilane
78-08-0

Triethoxyvinylsilane

N,N-Diethyl-3-methylbenzamide
134-62-3

N,N-Diethyl-3-methylbenzamide

C14H19NO

C14H19NO

Conditions
ConditionsYield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; lithium fluoride In 1,2-dichloro-ethane at 120℃; for 36h; Schlenk technique;68%

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The paper deals with the aqueous environmental fate of N,N-diethyl-m-toluamide (DEET), one of the most widespread and efficient mosquito repellents. The investigation involved monitoring of the DEET decomposition and the identification of intermediate compounds.Initially, control experiments in ...detailed

Electrochemical degradation of N,N-Diethyl-m-toluamide (cas 134-62-3) on a boron-doped diamond electrode07/11/2019

This study investigates the electrochemical oxidation of N,N-diethyl-m-toluamide (DEET) on a boron-doped diamond (BDD) anode under different temperatures, current densities, and sample matrixes. For comparison, a commercial Pt electrode and a lab-prepared PbO2 anode were also tested. The oxidati...detailed

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