Tetrahydrofuran-podands, stereoselective synthesis of trans-2,5-oligo-tetrahydrofurans

Article abstract of DOI:10.1016/S0040-4039(00)77598-8

Enantiomerically pure THF-podands 1 were synthesized along a linear route starting from lactone 3. A high degree of stereochemical control was achieved by chelation controlled addition of the functionalized Grignard reagent 7 to α-alkoxy-aldehydes of type 6.