Tetrahedron Letters p. 1999 - 2002 (1996)
Update date:2022-08-04
Topics:
Krotz, Achim H.
Cole, Douglas L.
Ravikumar, Vasulinga T.
Functionalized 2-(diphenylmethylsilyl)ethyl protected thymidyl-thymidine phosphorothioate dimers are easily accessible and stable under conditions used in oligophosphorothioate synthesis. Deprotection with ammonium hydroxide occurs through β-fragmentation. Methylamine and tetrabutyl-ammonium fluoride rapidly and selectively remove the DPSE protecting group of O,O,O-and O,O,S-trialkylphosphorothioates.
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