Thiazole-Based Stereoselective Routes to Leucine and Phenylalanine Hydroxyethylene Dipeptide Isostere Inhibitors of Renin and HIV-1 Aspartic Protease

Article abstract of DOI:10.1021/jo00129a037

A new synthesis of hydroxyethylene dipeptide isosteres for Leu-Leu and Phe-Phe in their γ-lactone form 1a and 1b employing β-amino-α-hydroxy aldehydes with singly and doubly protected nitrogen has been developed.These key intermediates, which are availabl