Synthesis of a novel fluoro-tribactam utilising an N-fluorosulfonimide in the key step

Article abstract of DOI:10.1016/0040-4020(95)00894-E

The electrophilic reagent N-fluorobenzenesulfonimide (NFSI) was used in the synthesis of the α-fluoro ketone 7, a key intermediate for the synthesis of the β-lactam 13. This highly reactive fluorinated tribactam 13 was rapidly hydrolysed in aqueous soluti