A convenient synthesis of 1-ethoxymethyl-5-nitro-6-substituted uracils

DOI: 10.1016/0040-4039(95)02368-2

Source and publish data:

Tetrahedron Letters p. 1031 - 1034 (1996)

Update date:2022-07-29

Topics:

Authors:

Benhida, Rachid

Aubertin, Anne-Marie

Grierson, David S.

Monneret, Claude

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Article abstract of DOI:10.1016/0040-4039(95)02368-2

Two new and versatile synthetic methods for preparing 5-nitro-analogues of HEPT and MKC-442 which are HIV-1 reverse transcriptase inhibitors, are reported. In both cases the key-step is based upon the displacement of a 6-methylthio or a 6-tosyl group by n

Full text of DOI:10.1016/0040-4039(95)02368-2

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