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52237-19-1

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Basic Information

Molecular Structure:
CAS No.:	52237-19-1
Name:	4-amino-3-(4-fluorophenyl)butanoic acid

Formula:	C₁₀H₁₂FNO₂
Molecular Weight:	197.209
Synonyms:	4-amino-3-(4-fluorophenyl)butyric acid;4-Amino-3-(4-fluoro-phenyl)-butyric acid;4-amino-3-(4-fluorophenyl)butanoic acid;d,l-4-amino-3-(4-fluorophenyl)-butyric acid;
Density:	1.244g/cm³
Boiling Point:	329.1°Cat760mmHg
Flash Point:	152.9°C
PSA:	63.32000
LogP:	2.04300

Synthetic route

: 38090-53-8
trans-4-aminocrotonic acid

: 459-45-0
4-fluorobenzenediazonium tetrafluoroborate

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

Conditions	Yield
With hydrogenchloride; titanium(III) chloride In water at 40℃; for 0.583333h; Meerwein arylation;	50%

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 71-36-3
butan-1-ol

: β-(p-fluorophenyl)-γ-aminobutyric acid butyl ester hydrochloride

Conditions	Yield
With hydrogenchloride at 105℃; for 0.5h;	89%

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 4-{2-[2-(4-Chloro-phenyl)-benzooxazol-5-yl]-propionylamino}-3-(4-fluoro-phenyl)-butyric acid butyl ester

Conditions	Yield
Multi-step reaction with 2 steps 1: 89 percent / 3 N HCl / 0.5 h / 105 °C 2: 75 percent / anhydrous sodium hydrogen carbonate / CH2Cl2 / 5 h / Ambient temperature View Scheme

: 1622940-09-3
1-({[(2-fluorophenyl)oxy]carbonyl}oxy)ethyl 2-methylpropanoate

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 1622940-12-8
4-{[(α-isobutanoyloxyethoxy)carbonyl]amino}-3(R)-(4-fluorophenyl)butanoic acid

Conditions	Yield
With triethylamine In n-heptane; water; acetonitrile at 10 - 20℃;

: 1622939-35-8
1-({[(3-fluorophenyl)oxy]carbonyl}oxy)ethyl 2-methylpropanoate

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 1622940-12-8
4-{[(α-isobutanoyloxyethoxy)carbonyl]amino}-3(R)-(4-fluorophenyl)butanoic acid

Conditions	Yield
With triethylamine In tert-butyl methyl ether; water; acetonitrile at 10 - 20℃; for 5h;

: 1622940-11-7
1-({[(4-trifluoromethylphenyl)oxy]carbonyl}oxy)ethyl 2-methylpropanoate

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 1622940-12-8
4-{[(α-isobutanoyloxyethoxy)carbonyl]amino}-3(R)-(4-fluorophenyl)butanoic acid

Conditions	Yield
With triethylamine In tert-butyl methyl ether; water; acetonitrile at 10 - 20℃; for 5h;

: 1622939-42-7
1-({[(4-methoxycarbonylphenyl)oxy]carbonyl}oxy)ethyl 2-methylpropanoate

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 1622940-12-8
4-{[(α-isobutanoyloxyethoxy)carbonyl]amino}-3(R)-(4-fluorophenyl)butanoic acid

Conditions	Yield
With triethylamine In tert-butyl methyl ether; water; acetonitrile at 10 - 20℃; for 5h;

: 1622939-45-0
1-({[(3,4-methylenedioxyphenyl)oxy]carbonyl}oxy)ethyl 2-methylpropanoate

: 52237-19-1
β-(p-fluorophenyl)-γ-aminobutyric acid

: 1622940-12-8
4-{[(α-isobutanoyloxyethoxy)carbonyl]amino}-3(R)-(4-fluorophenyl)butanoic acid

Conditions	Yield
With triethylamine In tert-butyl methyl ether; water; acetonitrile at 10 - 20℃; for 5h;

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