Tetrahedron p. 6085 - 6116 (1996)
Update date:2022-08-05
Topics:
Clive, Derrick L. J.
Kong, Xianglong
Paul, Christine Chua
The fredericamycin A analogues 5 and 23 were synthesized. A key step is the process of radical spirocyclization, and the diastereoselectivity of this reaction was studied with model compounds. In vitro tests showed that 23 was active against certain cell lines of colon and prostate cancer, while compound 5 was essentially inactive.
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Doi:10.1021/ja953872n
(1996)Doi:10.1002/jhet.5570330238
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(1996)Doi:10.1016/0277-5387(95)00503-X
(1996)Doi:10.1016/0040-4039(96)00587-4
(1996)