Synthesis of GLA-60 positional isomer as an LPS-agonist and its activity

DOI: 10.1246/cl.1996.735

Source and publish data:

Chemistry Letters p. 735 - 736 (1996)

Update date:2022-07-29

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Authors:

Shiozaki, Masao

Arai, Masami

Macindoe, Wallace M.

Mochizuki, Takashi

Kurakata, Shin-Ichi

Maeda, Hiroaki

Nishijima, Masahiro

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Article abstract of DOI:10.1246/cl.1996.735

Compound 10 was synthesized from β-D-glucose pentaacetate in a stereocontrolled manner. It unexpectedly showed LPS-agonistic activity much stronger than that of GLA-60 toward human monoblastic U937 cells in the TNFα production.

Full text of DOI:10.1246/cl.1996.735

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