Asymmetric synthesis of cis-(-)-(2R4S)-4-(phosphonomethyl)-2-piperidinecarboxylic acid, a potent NMDA receptor antagonist

DOI: 10.1016/0960-894X(96)00150-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 963 - 966 (1996)

Update date:2022-09-26

Topics:

Authors:

Skiles, Jerry W.

Giannousis, Peter P.

Fales, Kevin R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00150-3

The asymmetric synthesis of cis-(-)-(2R4S)-4-(phosphononomethyl)-2-piperidinecarboxylic acid (1), a potent and specific NMDA receptor antagonist, via an olefin-iminium cyclization is described.

Full text of DOI:10.1016/0960-894X(96)00150-3

Products guided by the article

Product name:(1S,5R)-2-[(1R)-1-phenylethyl]-6-oxa-2-azabicyclo[3.2.1]octan-7-one

Cas No:178035-47-7

R&D Labs maybe for 178035-47-7

Changzhou Litong Chemical Co., Ltd.

website:http://www.litonchem.com/

Contact:+86-519-86301238

Address:Laoba Rd, Hutang town Changzhou Jiangsu
Changzhou Ruiping Chemical Co., Ltd

website:http://www.wishchem.com

Contact:+86-519-82324280

Address:No.288-1 Huacheng Road, Jintan
Taizhou Elitechemie MediPharma Technology Co.,Ltd.

Contact:+86-523-86810021

Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
A.M FOOD CHEMICAL CO., LIMITED

Contact:86-531-87100375

Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
MTT Pharma & Bio-technology Co.,Ltd(expird)

Contact:+86-21-58407925

Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China

Relevant to this article

Imidazolylidene carbene ligated palladium catalysis of the Heck reaction in the presence of air.

Doi:10.1039/b306715g
(2003)
A versatile synthesis of a β-turn peptidomimetic scaffold: An approach towards a designed model antagonist of the tachykinin NK-2 receptor

Doi:10.1016/S0960-894X(96)00275-2
(1996)
Reactions of cyano-iron and -ruthenium compounds with gem-dicyano-epoxides. A new pathway to vinyl isocyanide complexes of iron and ruthenium

Doi:10.1039/dt9960003231
(1996)
Tungsten(II) chlorocarbonyls as alkene metathesis, arene alkylation and alkyne polymerization catalysts

Doi:10.1016/S1381-1169(97)00059-9
(1997)
Synthetic applications of 2-(1,3-dithian-2-yl)indoles. 7. Synthesis of aspidospermidine

Doi:10.1021/jo9609900
(1996)
Doi:10.1021/ja01468a040
(1961)

Article Doi