Asymmetric synthesis of cis-(-)-(2R4S)-4-(phosphonomethyl)-2-piperidinecarboxylic acid, a potent NMDA receptor antagonist

DOI: 10.1016/0960-894X(96)00150-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 963 - 966 (1996)

Update date:2022-09-26

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Authors:

Skiles, Jerry W.

Giannousis, Peter P.

Fales, Kevin R.

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Article abstract of DOI:10.1016/0960-894X(96)00150-3

The asymmetric synthesis of cis-(-)-(2R4S)-4-(phosphononomethyl)-2-piperidinecarboxylic acid (1), a potent and specific NMDA receptor antagonist, via an olefin-iminium cyclization is described.

Full text of DOI:10.1016/0960-894X(96)00150-3

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