ACS Medicinal Chemistry Letters p. 776 - 781 (2015)
Update date:2022-08-02
Topics:
Karpov, Alexei S.
Amiri, Payman
Bellamacina, Cornelia
Bellance, Marie-Helene
Breitenstein, Werner
Daniel, Dylan
Denay, Regis
Fabbro, Doriano
Fernandez, Cesar
Galuba, Inga
Guerro-Lagasse, Stephanie
Gutmann, Sascha
Hinh, Linda
Jahnke, Wolfgang
Klopp, Julia
Lai, Albert
Lindvall, Mika K.
Ma, Sylvia
M?bitz, Henrik
Pecchi, Sabina
Rummel, Gabriele
Shoemaker, Kevin
Trappe, Joerg
Voliva, Charles
Cowan-Jacob, Sandra W.
Marzinzik, Andreas L.
The discovery of inhibitors targeting novel allosteric kinase sites is very challenging. Such compounds, however, once identified could offer exquisite levels of selectivity across the kinome. Herein we report our structure-based optimization strategy of
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