Isolation and structure of wightional and wightiolide from Andrographis wightiana

Article abstract of DOI:10.1016/0031-9422(95)00946-9

Two new ent-labdane-type diterpenoids, wightional and wightiolide have been isolated from the leaves of Andrographis wightiana. Their structures were determined on the basis of extensive ¹H and ¹³C, ¹H homonuclear COSY, and HMBC NMR spectroscopic studies. To correlate the newly isolated diterpenes with wightionolide, a number of derivatives of wightionolide have been prepared and characterized.