Chemistry - An Asian Journal p. 765 - 769 (2018)
Update date:2022-08-03
Topics:
Wang, Liang
Liu, Xi
Liu, Jian-Biao
Shen, Jun
Chen, Qun
He, Ming-Yang
A RhIII-catalysed three-component synthesis of isoindolinone frameworks via direct assembly of benzoyl chlorides, o-aminophenols and activated alkenes has been developed. The process involves in situ generation of o-aminophenol (OAP)-based bidentate directing group (DG), RhIII-catalysed tandem ortho C?H olefination and subsequent cyclization via aza-Michael addition. This protocol exhibits good chemoselectivity and functional group tolerance. Computational studies showed that the presence of hydroxyl group on the N-aryl ring could enhance the chemoselectivity of the reaction.
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Doi:10.1002/cjoc.201400829
(2015)Doi:10.1021/jm000148t
(2000)Doi:10.1021/jo800246g
(2008)Doi:10.1016/0960-894X(96)00215-6
(1996)Doi:10.1039/p19960001365
(1996)Doi:10.1021/ja01152a093
(1951)
