Bioorganic and Medicinal Chemistry Letters p. 1145 - 1150 (1996)
Update date:2022-09-26
Topics:
Curtis, Neil R.
Kulagowski, Janusz J.
Leeson, Paul D.
Mawer, Ian M.
Ridgill, Mark P.
Rowley, Michael
Grimwood, Sarah
Marshall, George R.
A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety. Copyright
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(1996)
