Synthesis and sar of dhodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

DOI: 10.1016/0960-894X(96)00187-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1145 - 1150 (1996)

Update date:2022-09-26

Topics:

Authors:

Curtis, Neil R.

Kulagowski, Janusz J.

Leeson, Paul D.

Mawer, Ian M.

Ridgill, Mark P.

Rowley, Michael

Grimwood, Sarah

Marshall, George R.

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Article abstract of DOI:10.1016/0960-894X(96)00187-4

A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety. Copyright

Full text of DOI:10.1016/0960-894X(96)00187-4

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