The use of aliphatic aldehydes for the synthesis of 4-alkyl-6-amino-3,5-dicyanopyridine-2(1h)-thiones

Article abstract of DOI:10.1007/BF01431320

The condensation of aliphatic aldehydes with malononitrile and cyanothioacetamide gives 4-alkyl-2,6-diamino-3,5-dicyano-4H-thiopyrans which recyclize into 4-alkyl-6-amino-3,5-dicyanopyridine-2(1H)-thiones. The latter are easily S-alkylated with α-haloacetonitriles and α-haloacetophenones.