New cyclization mechanism for squalene: A ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis

Article abstract of DOI:10.1271/bbb.63.2038

Three triterpenes having the 6/6/5-fused tri- and 6/6/6/5-fused tetracyclic skeletons were isolated from an incubation mixture of the mutated F601A enzyme, these products being in accordance with a Markovnikov closure. Successful trapping of the tricyclic