Synthesis of achiral and homochiral dibenzo[b,f]phosphepin 5-oxides using bromine/lithium exchange. X-ray structure of (10R, 11R)-10,11-dihydroxy-10,11-dihydro-5-phenyl-5H-dibenzo[b,f]phosphepin 5-oxide

Article abstract of DOI:10.1016/0040-4039(96)01137-9

An improved synthesis of 5-phenyldibenzo[b,f]phosphepin 5-oxide by a seven step one-pot procedure and the synthesis of enantiomerically pure 5-phenyl- and 5-propyldibenzo[b,f]phosphepin 5-oxides by use of McMurry coupling, Sharpless dihydroxylation and a bromine-lithium exchange strategy is described.