Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D

DOI: 10.1016/0960-894X(96)00393-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2157 - 2162 (1996)

Update date:2022-08-04

Topics:

Authors:

Whitesitt, Celia A.

Simon, Richard L.

Reel, Jon K.

Sigmund, Sandra K.

Phillips, Michael L.

Shadle, J. Kevin

Heinz, Lawrence J.

Koppel, Gary A.

Hunden, David C.

Lifer, Sherryl L.

Berry, Dennis

Ray, Judy

Little, Sheila P.

Liu, Xiadong

Marshall, Winston S.

Panetta, Jill A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00393-9

Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimer's disease, were prepared and evaluated. The most potent inhibitor of cathepsin D in this series was found to be (Z)-5-[[4-(4-be

Full text of DOI:10.1016/0960-894X(96)00393-9

Products guided by the article

Product name:4-(3-Hydroxy-4-propionyl-2-propyl-benzyloxy)-benzaldehyde

Cas No:183013-48-1

R&D Labs maybe for 183013-48-1

wuxi huabin bio-tech Co.,Ltd(expird)

Contact:86-0510-85133006

Address:hubin road NO157
Zibo Fuxi'er Chemical Co.,Ltd （Shanxian Fuxi'er Chemical Co.,Ltd）

Contact:+86-533-2091422

Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Anhui New Star Pharmaceutical Development Co., Ltd

Contact:013956922763

Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Shanghai FWD Chemicals ltd

website:http://www.fwdchem.com

Contact:86-21-54450828

Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Hunan Dinuo Pharmaceutical Co.,Ltd.

Contact:86-731-88280100*8561

Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China

Relevant to this article

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine inhibitors of farnesyl-protein transferase: Design and synthesis of in vivo active antitumor compounds

Doi:10.1021/jm970464g
(1997)
Diels-Alder reactions of chiral 1,3-dienes

Doi:10.1021/jo9609743
(1996)
Chemistry of the 1,3,5-triaza-2-phosphorin-4,6-diones, part XII. Synthesis and characterization of 2-phenyl-2-(p-tolylthio)-1,3,5-trimethyl-1,3,5-triaza-4,6-dione-2- phosphorinonium salts

Doi:10.1515/znb-1996-1021
(1996)
A total synthesis of nannochelin A. A short route to optically active N^ω-hydroxy-α-amino acid derivatives

Doi:10.1021/jo961458f
(1996)
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent

Doi:10.1128/AAC.02600-14
(2014)
Erratum: "PMA-SiO2-Mediated MCR in PEG-400: A Greener Aza-Friedel-Crafts Reaction Leading to 3-Arylmethyl/Diarylmethyl Indoles" (Synthetic Communications (2015) 45:4 (513-523) DOI: 10.1080/00397911.2014.966392)

Doi:10.1080/00397911.2015.1087250
(2015)

Article Doi