Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D

DOI: 10.1016/0960-894X(96)00393-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2157 - 2162 (1996)

Update date:2022-08-04

Topics:

Authors:

Whitesitt, Celia A.

Simon, Richard L.

Reel, Jon K.

Sigmund, Sandra K.

Phillips, Michael L.

Shadle, J. Kevin

Heinz, Lawrence J.

Koppel, Gary A.

Hunden, David C.

Lifer, Sherryl L.

Berry, Dennis

Ray, Judy

Little, Sheila P.

Liu, Xiadong

Marshall, Winston S.

Panetta, Jill A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00393-9

Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimer's disease, were prepared and evaluated. The most potent inhibitor of cathepsin D in this series was found to be (Z)-5-[[4-(4-be

Full text of DOI:10.1016/0960-894X(96)00393-9

Products guided by the article

Product name:4-(3-Hydroxy-4-propionyl-2-propyl-benzyloxy)-benzaldehyde

Cas No:183013-48-1

R&D Labs maybe for 183013-48-1

Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District
sichuan tiancai fine co LTD.

website:http://www.tcfinechem.com/

Contact:18681346930

Address:baifu town,whou district
Tianjin Emulsion Science&Technology Development Co.,Ltd

Contact:13901380442

Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China
EnBridge PharmTech Co., Ltd.

website:http://www.enbridgepharm.com

Contact:+86-510-83591909

Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China

Relevant to this article

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine inhibitors of farnesyl-protein transferase: Design and synthesis of in vivo active antitumor compounds

Doi:10.1021/jm970464g
(1997)
Diels-Alder reactions of chiral 1,3-dienes

Doi:10.1021/jo9609743
(1996)
Chemistry of the 1,3,5-triaza-2-phosphorin-4,6-diones, part XII. Synthesis and characterization of 2-phenyl-2-(p-tolylthio)-1,3,5-trimethyl-1,3,5-triaza-4,6-dione-2- phosphorinonium salts

Doi:10.1515/znb-1996-1021
(1996)
A total synthesis of nannochelin A. A short route to optically active N^ω-hydroxy-α-amino acid derivatives

Doi:10.1021/jo961458f
(1996)
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent

Doi:10.1128/AAC.02600-14
(2014)
Erratum: "PMA-SiO2-Mediated MCR in PEG-400: A Greener Aza-Friedel-Crafts Reaction Leading to 3-Arylmethyl/Diarylmethyl Indoles" (Synthetic Communications (2015) 45:4 (513-523) DOI: 10.1080/00397911.2014.966392)

Doi:10.1080/00397911.2015.1087250
(2015)

Article Doi