Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D

DOI: 10.1016/0960-894X(96)00393-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2157 - 2162 (1996)

Update date:2022-08-04

Topics:

Authors:

Whitesitt, Celia A.

Simon, Richard L.

Reel, Jon K.

Sigmund, Sandra K.

Phillips, Michael L.

Shadle, J. Kevin

Heinz, Lawrence J.

Koppel, Gary A.

Hunden, David C.

Lifer, Sherryl L.

Berry, Dennis

Ray, Judy

Little, Sheila P.

Liu, Xiadong

Marshall, Winston S.

Panetta, Jill A.

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Article abstract of DOI:10.1016/0960-894X(96)00393-9

Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimer's disease, were prepared and evaluated. The most potent inhibitor of cathepsin D in this series was found to be (Z)-5-[[4-(4-be

Full text of DOI:10.1016/0960-894X(96)00393-9

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Product name:4-(3-Hydroxy-4-propionyl-2-propyl-benzyloxy)-benzaldehyde

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