Biologically selective potassium channel openers having 1,1- diethylpropyl group

DOI: 10.1016/S0960-894X(98)00625-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3397 - 3402 (1998)

Update date:2022-08-05

Topics:

Authors:

Yoshiizumi, Kazuya

Seko, Norihiko

Nishimura, Noriyasu

Ikeda, Shoji

Yoshino, Kohichiro

Kondo, Hirosato

Tanizawa, Kazutaka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00625-8

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

Full text of DOI:10.1016/S0960-894X(98)00625-8

Products guided by the article

Product name:Benzonitrile, 3-chloro-5-isothiocyanato-

Cas No:185500-56-5

R&D Labs maybe for 185500-56-5

Jiangsu Cale New Material Co.ltd

Contact:+86-515-88334667/88203550

Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
XZL BIO-TECHNOLOGY CO., LTD.

Contact:0086 533 2282832

Address:Zibo，Shandong
Chongqing Changfeng Chemical Co., Ltd.

website:http://www.changfengchem.com

Contact:+86-23-67896333

Address:30th Floor, Longhu Ziduxingzuo Building A, 1st Branch,YuSong Rd., Yubei District, Chongqing, China
Shanghai Dianyang Industry Co.,ltd

Contact:+86 21 6492 4669

Address:Chejing RD, Songjiang District, Shanghai, China
Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)

Contact:+86-512-69598882

Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China

Relevant to this article

Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Doi:10.1016/S0960-894X(99)00582-X
(2000)
Efficient asymmetric synthesis of (R)-3-hydroxy- and alkanoyloxytetradecanoic acids and method for the determination of enantiomeric purity

Doi:10.1016/S0957-4166(96)00464-8
(1996)
Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Doi:10.3987/COM-99-8689
(2000)
Sunlight-Driven Synthesis of Triarylethylenes (TAEs) via Metal-Free Mizoroki–Heck-Type Coupling

Doi:10.1002/ejoc.201800883
(2018)
Doi:10.1007/BF00848993
()
2,5-Bis-trimethylsilyl substituted boroles

Doi:10.1039/d0dt00393j
(2020)

Article Doi