Biologically selective potassium channel openers having 1,1- diethylpropyl group

DOI: 10.1016/S0960-894X(98)00625-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3397 - 3402 (1998)

Update date:2022-08-05

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Authors:

Yoshiizumi, Kazuya

Seko, Norihiko

Nishimura, Noriyasu

Ikeda, Shoji

Yoshino, Kohichiro

Kondo, Hirosato

Tanizawa, Kazutaka

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Article abstract of DOI:10.1016/S0960-894X(98)00625-8

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

Full text of DOI:10.1016/S0960-894X(98)00625-8

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