Biologically selective potassium channel openers having 1,1- diethylpropyl group

DOI: 10.1016/S0960-894X(98)00625-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3397 - 3402 (1998)

Update date:2022-08-05

Topics:

Authors:

Yoshiizumi, Kazuya

Seko, Norihiko

Nishimura, Noriyasu

Ikeda, Shoji

Yoshino, Kohichiro

Kondo, Hirosato

Tanizawa, Kazutaka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00625-8

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

Full text of DOI:10.1016/S0960-894X(98)00625-8

Products guided by the article

Product name:Benzonitrile, 3-chloro-5-isothiocyanato-

Cas No:185500-56-5

R&D Labs maybe for 185500-56-5

Xi'an HO-SHINE Bio-Technology Co., Ltd

Contact:+86 (29) 8248-5435/18292020086

Address:No.6 Shiyuan Road Xian City Shaanxi Province, 710048 China
Jiangxi Hito Chemical Co., Ltd.

Contact:+86-792-3170318

Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
GenicBio Limited

Contact:+86-(0)21-3770 9035

Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Sinonine Industry Co.,Ltd

Contact:86+21-56421993

Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Beijing Cooperate Pharmaceutical Co.,Ltd

website:http://www.cooperate-pharm.com/

Contact:86-01060279497

Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base

Relevant to this article

Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Doi:10.1016/S0960-894X(99)00582-X
(2000)
Efficient asymmetric synthesis of (R)-3-hydroxy- and alkanoyloxytetradecanoic acids and method for the determination of enantiomeric purity

Doi:10.1016/S0957-4166(96)00464-8
(1996)
Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Doi:10.3987/COM-99-8689
(2000)
Sunlight-Driven Synthesis of Triarylethylenes (TAEs) via Metal-Free Mizoroki–Heck-Type Coupling

Doi:10.1002/ejoc.201800883
(2018)
Doi:10.1007/BF00848993
()
2,5-Bis-trimethylsilyl substituted boroles

Doi:10.1039/d0dt00393j
(2020)

Article Doi