Tetrahedron Asymmetry p. 3559 - 3564 (1996)
Update date:2022-08-05
Topics:
Keegan, David S.
Hagen, Steven R.
Johnson, David A.
An efficient synthesis of the (R)-3-hydroxy- and alkanoyloxytetradecanoic acid components of bacterial lipid A has been achieved using a Ru(II)-Binap-catalyzed low-pressure hydrogenation in the key step. The enantiomeric purity of p-bromophenacyl ester intermediate 4 could be assessed directly by chiral HPLC - obviating separate derivatization steps and/or chiral NMR shift studies.
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