Dephosphonylation of protected deoxynucleoside and oligodeoxynucleotide H-phosphonates

Article abstract of DOI:10.1016/S0040-4039(99)01185-5

The conversion of four 5'-O-(4,4'-dimethoxytrityl)-2'- deoxyribonucleoside 3'-H-phosphonates 1 (B=4, 5, 6 and 7) into their partially-protected nucleoside precursors 3 (B=4, 5, 6 and 7, respectively) in good isolated yields is described. The procedure used is also suitable for the dephosphonylation of protected oligonucleotide H-phosphonate blocks.