138786-67-1Relevant articles and documents
Synthetic method and application of pantoprazole sodium
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Paragraph 0027-0028; 0031-0034; 0037-0040; 0043-0046; ..., (2021/07/28)
The invention belongs to the field of medicine synthesis, and discloses a synthesis method and application of pantoprazole sodium. The pantoprazole sodium is synthesized by the following steps: firstly carrying out sulfinylation on 5-difluoromethoxy-2-sulfenyl-1H-benzimidazole, and then carrying out Suzuki reaction on the 5-difluoromethoxy-2-sulfenyl-1H-benzimidazole and ((3, 4-dimethoxypyridine-2-yl) methyl) boric acid. According to the invention, the synthesis method of pantoprazole sodium provided by the invention can effectively improve the utilization rate of raw materials, improve the yield of intermediates and further reduce the production cost; the purification process of the synthesized intermediate and the final product in the synthesis method is simple, and the technological process is further shortened; and the synthesis method provided by the invention is suitable for synthesizing pantoprazole sodium, and the synthesized pantoprazole sodium is used for preparing a pantoprazole sodium injection.
Preparation of Pantoprazole sodium method and Pantoprazole sodium (by machine translation)
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, (2019/02/27)
The invention relates to the preparation of Pantoprazole sodium method and pantoprazole sodium. In particular, the invention relates to a method of preparing pantoprazole sodium, comprising the following steps: 1) to 2 - hydroxymethyl - 3, 4 - dimethoxy pyridine (II) as the starting material, in under the action of chloride, the compound of formula III; 2) will be of the formula III compound in the presence of an inorganic base with 5 - difluoro - 2 - mercapto - 1 H - benzimidazole condensation, the compound of formula IV; 3) will be of the formula IV compound is oxidized by an oxidant generating 5 - difluoro - 2 - [(3, 4 - dimethoxy - 2 - pyridyl) methyl] sulfinyl - 1 H - benzimidazole is pantoprazole; 4) the obtained 5 - difluoro - 2 - [(3, 4 - dimethoxy - 2 - pyridyl) methyl] sulfinyl - 1 H - benzimidazole with sodium hydroxide reaction to produce salt that pantoprazole sodium (I); and optionally a 5) the resulting pantoprazole sodium is refined. The method of the invention said product has high purity, and the related impurities such as oxidation impurity, reducing the impurity, decomposition low impurity content. (by machine translation)
Method for refining pantoprazole sodium
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Paragraph 0033; 0036; 0037; 0038; 0041; 0042; 0043; 0046, (2018/09/28)
The invention discloses a method for refining pantoprazole sodium. The method comprises the following steps: suspending a crude product of pantoprazole sodium in an ethanol-water mixed solution, adjusting the pH value to be 7.0-8.0 by using 1mol/L of hydrochloric acid, washing, and drying so as to obtain pantoprazole; dissolving pantoprazole into a mixed liquid of methanol and dichloromethane, dropping a sodium hydroxide-water solution, filtering a crystal, washing, and drying in vacuum, so as to obtain medicinal-grade pantoprazole sodium. The method is simple and convenient to operate, low inrefining cost and applicable to industrial amplification operation, and the prepared pantoprazole sodium is high in yield, high in purity, low in solvent residue, good in color and good in stability.