Enantioselective syntheses of (R)-3-phenyl GABA, (R)-baclofen and 4-arylpyrrolidin-2-ones

Article abstract of DOI:10.1016/S0040-4020(96)00946-5

Enantioselective synthesis of (R)-4-amino-3-phenylbutyric acid and (R)-baclofen has been achieved through a diastereoselective conjugate addition of cyanide to enantiomerically pure 2-(2-arylethenyl)oxazolines, followed by chemoselective reduction into cyclic amidines.