Enantioselective Synthesis of α-Hydroxyketones using the DiTOX Asymmetric Building Block

Article abstract of DOI:10.1016/S0040-4039(96)02050-3

The 2-(R)- and 2-(S)-hydroxy-1-phenylbutan-1-ones have been prepared in high enantiomeric excesses and in five steps from propanal using a dithiane oxide unit as an asymmetric building block and a modified Sharpless enantioselective sulphur oxidation as the source of chirality.