Recognition of a G-C base pair by α-N7-deoxyinosine within the pyrimidine-purine-pyrimidine DNA triple helical motif

DOI: 10.1016/S0960-894X(96)00561-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3021 - 3024 (1996)

Update date:2022-08-02

Topics:

Authors:

Marfurt, Judith

Hunziker, Juerg

Leumann, Christian

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Article abstract of DOI:10.1016/S0960-894X(96)00561-6

The α-nucleoside 7-(2'-deoxy-α-D-ribofuranosyl)hypoxanthine, incorporated into an otherwise β-configured oligodeoxynucleotide that is designed to bind to a DNA duplex in the parallel motif, recognizes selectively and efficiently a G-C base pair, presumably via monodentate α-H⁷·G-C base-triple formation.

Full text of DOI:10.1016/S0960-894X(96)00561-6

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