An efficient synthesis of methyl Tetra-O-hexyl gentiooctaoside, an octaosyl analogue of ANP receptor antagonist HS-142-1

Article abstract of DOI:10.1016/S0968-0896(96)00214-3

Methyl O-(3-O-hexyl-β-D-glucopyranosyl)-(1→6)[-O-(β-D- glucopyranosyl)-(1→6)[[[-O-(3-O-hexyl-β-D-glucopyranosyl)-(1→6)]₃-β-D -glucopyranoside, a 3-O hexyl analogue of the octaosyl component of fungal lipooligosaccharide HS-142-1, was stereo- and regioselectively synthesized as a potent antagonist for the tetrameric atrial natriuretic peptide (ANP) receptors.