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Palmidrol
Cas No: 544-31-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
manufacturer High purity in stock Palmitoylethanolamide(PEA 99%) 544-31-0
Cas No: 544-31-0
USD $ 1.8-1.8 / Gram 1 Gram 100 Metric Ton/Month GIHI CHEMICALS CO.,LIMITED Contact Supplier
Natural Pain Killer Palmitoylethanolamide PEA
Cas No: 544-31-0
USD $ 70.0-130.0 / Kilogram 1 Kilogram 1 Metric Ton/Week Shaanxi Yuantai Biological Technology Co., Ltd. Contact Supplier
98% up PALMITOYLETHANOLAMIDE Palmidrol PEA 544-31-0
Cas No: 544-31-0
No Data 1 Kilogram 10 Metric Ton/Month Sinoway Industrial Co., Ltd. Contact Supplier
High Quality 99% Palmitoylethanolamide (PEA) 544-31-0 GMP Manufacturer
Cas No: 544-31-0
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Bulk supply PEA Palmitoylethanolamide 99% Palmitoylethanolamide powder CAS NO.544-31-0
Cas No: 544-31-0
USD $ 30.0-50.0 / Kilogram 1 Kilogram 500 Kilogram/Month Mike(Wuhan) Biotechnology Co.,Ltd Contact Supplier
High quality Palmitoylethanolamide
Cas No: 544-31-0
USD $ 100.0-100.0 / Kilogram 1 Kilogram 1-1000 Metric Ton/Day Metric Ton/Day Zibo Hangyu Import&Export Co., Ltd Contact Supplier
High quality Palmitoylethanolamide(PEA 99%) for hot sale
Cas No: 544-31-0
No Data No Data No Data Wuxi TAA Chemical Industry Co.,LTD. Contact Supplier
Bulk supply PEA Palmitoylethanolamide 99% Palmitoylethanolamide powder
Cas No: 544-31-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
PEA , factory supply Palmitoylethanolamide Palmidrol with best price
Cas No: 544-31-0
USD $ 80.0-100.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Shanghai Bokchang Chemical Science and Technology Co.,Ltd Contact Supplier

544-31-0 Usage

Definition

ChEBI: An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.

Uses

antiinflammatory

Chemical Properties

white powder

Biological Activity

Endogenous lipid that acts as a selective GPR55 agonist (EC 50 values are 4, 19 800 and > 30 000 nM at GPR55, CB 2 and CB 1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo . Directly activates PPAR α (EC 50 = 3 μ M) producing robust anti-inflammatory actions.
InChI:InChI=1/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

544-31-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (P0359)  Palmitoylethanolamide   544-31-0 P0359-10MG 840.06CNY Detail
Sigma (P0359)  Palmitoylethanolamide   544-31-0 P0359-50MG 3,753.36CNY Detail

544-31-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name palmitoyl ethanolamide

1.2 Other means of identification

Product number -
Other names N-(2-hydroxyethyl)hexadecanamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:544-31-0 SDS

544-31-0Synthetic route

ethanolamine
141-43-5

ethanolamine

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
Stage #1: 1-hexadecylcarboxylic acid In water at 100℃; for 2h;
Stage #2: ethanolamine In water at 100 - 200℃; for 22h;
98.2%
With Novozym 435 In 1,4-dioxane for 0.0666667h; Microwave irradiation; Enzymatic reaction; chemoselective reaction;97.3%
Stage #1: 1-hexadecylcarboxylic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h;
Stage #2: ethanolamine In dichloromethane for 12h;
96%
hexadecanoic acid ethyl ester
628-97-7

hexadecanoic acid ethyl ester

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
With Novozym 435 In 1,4-dioxane for 0.0666667h; Microwave irradiation; Enzymatic reaction; chemoselective reaction;97.5%
ethanolamine
141-43-5

ethanolamine

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
With triethylamine In dichloromethane a) 0 deg C, 30 min, b) RT, 2 h;97%
With magnesium oxide In tetrahydrofuran; water at 20℃; for 2h;92%
With sodium carbonate In diethyl ether
vinyl palmitate
693-38-9

vinyl palmitate

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
With sodium methylate at 60℃; for 1.5h; Neat (no solvent);96.5%
With sodium methylate at 60℃; for 1.5h; Concentration; Temperature; Time;
With potassium methanolate In methanol at 65℃; for 3h;
glyceroltripalmitate
555-44-2

glyceroltripalmitate

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
at 50 - 60℃; for 8h;95.4%
ethanolamine
141-43-5

ethanolamine

Stearoyl chloride
112-76-5

Stearoyl chloride

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h; Cooling with ice;95%
ethanolamine
141-43-5

ethanolamine

C28H40N2O2
100663-86-3

C28H40N2O2

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In dichloromethane for 2h; Ambient temperature;92%
1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one
74058-64-3

1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In dichloromethane for 0.333333h; Ambient temperature;91%
In dichloromethane for 0.333333h; Product distribution; Ambient temperature; other aminoalcohols and aminophenols in further solvents;91%
palmitic acid isopropyl ester
142-91-6

palmitic acid isopropyl ester

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
With sodium ethanolate In methanol; ethanol at 60℃; for 4h; Inert atmosphere;89%
N-hexadecanoyl glycine methyl ester
214706-34-0

N-hexadecanoyl glycine methyl ester

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 0.75h; Ambient temperature;
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

thorium oxide

thorium oxide

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: DCC-DMAP
2: 92 percent / CH2Cl2 / 2 h / Ambient temperature
View Scheme
n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

ent-17-methyl-morphinan-3-ol

ent-17-methyl-morphinan-3-ol

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N
2: 92 percent / CH2Cl2 / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: Et3N / tetrahydrofuran / 20 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 0.75 h / Ambient temperature
View Scheme
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dicyclohexylcarbodiimide
2: 91 percent / CH2Cl2 / 0.33 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid
2: acetonitrile / 24 h
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
2: triethylamine / 3 h
View Scheme
ethanolamine
141-43-5

ethanolamine

palmitoyl ethyl carbonate
120246-99-3

palmitoyl ethyl carbonate

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In dichloromethane at 0 - 10℃; Product distribution / selectivity;
In cyclohexane at 0 - 10℃; Product distribution / selectivity;
C18H34O4

C18H34O4

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In dichloromethane at 20℃; Cooling with ice;
In chloroform at 0 - 10℃; Product distribution / selectivity;
C22H40O4

C22H40O4

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In dichloromethane at 0 - 10℃; Product distribution / selectivity;
hexadecanoic acid methyl ester
112-39-0

hexadecanoic acid methyl ester

ethanolamine
141-43-5

ethanolamine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Conditions
ConditionsYield
In acetonitrile for 24h;
In acetonitrile for 24h;
With zeolite H-beta-22 In hexane at 180℃; under 15001.5 Torr; for 3h; Reagent/catalyst; Inert atmosphere;
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

N-palmitoyl glycine
2441-41-0

N-palmitoyl glycine

Conditions
ConditionsYield
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; sodium hydroxide In tetrahydrofuran; water for 1.5h; Reagent/catalyst; Industrial scale; Green chemistry;98.5%
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-valinate

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-valinate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 23℃; for 12h; Steglich Esterification; Inert atmosphere;95%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

N-[2-(benzylaminocarbonyl)-oxyethyl]-hexadecanamide

N-[2-(benzylaminocarbonyl)-oxyethyl]-hexadecanamide

Conditions
ConditionsYield
Stage #1: 2-(palmitoylamino)ethanol With 4 Å molecular sieves In toluene Heating / reflux;
Stage #2: benzyl isothiocyanate With 4 Å molecular sieves for 6h; Heating / reflux;
94%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-[2-(ethoxycarbonyl)-oxyethyl]-hexadecanamide

N-[2-(ethoxycarbonyl)-oxyethyl]-hexadecanamide

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at 20 - 45℃; for 3h;93%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

1-acetoxy-2-palmitoylamino-ethane
2495-72-9

1-acetoxy-2-palmitoylamino-ethane

Conditions
ConditionsYield
With acetic anhydride In pyridine93%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Glycine ethyl ester isocyanate
2949-22-6

Glycine ethyl ester isocyanate

N-[[2-(ethoxycarbonylmethyl)-aminocarbonyl]-oxyethyl]-hexadecanamide

N-[[2-(ethoxycarbonylmethyl)-aminocarbonyl]-oxyethyl]-hexadecanamide

Conditions
ConditionsYield
Stage #1: 2-(palmitoylamino)ethanol With 4 Å molecular sieves In toluene Heating / reflux;
Stage #2: Glycine ethyl ester isocyanate With 4 Å molecular sieves for 6h; Heating / reflux;
92%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

2-pentadecyl-2-oxazoline
36919-66-1

2-pentadecyl-2-oxazoline

Conditions
ConditionsYield
Stage #1: 2-(palmitoylamino)ethanol With thionyl chloride at 0 - 20℃; for 15.5h; Inert atmosphere;
Stage #2: With potassium tert-butylate In toluene at 40℃; for 2h;
92%
Multi-step reaction with 2 steps
1: thionyl chloride / 15.5 h / 0 - 20 °C / Inert atmosphere
2: potassium tert-butylate / toluene / 2 h / 40 °C
View Scheme
2,3-dihydro-2H-furan
1191-99-7

2,3-dihydro-2H-furan

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

tetrahydrofuranyl ether of N-(2-hydroxyethyl)-hexadecanamide

tetrahydrofuranyl ether of N-(2-hydroxyethyl)-hexadecanamide

Conditions
ConditionsYield
With pyridinium methanesulfonate at 4 - 50℃; for 1h;90%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Boc-D-Val-OH
22838-58-0

Boc-D-Val-OH

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-D-valinate

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-D-valinate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 23℃; for 12h; Steglich Esterification; Inert atmosphere;89%
L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-alaninate

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-alaninate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 23℃; for 12h; Steglich Esterification; Inert atmosphere;84%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

pyrophosphoric acid
14000-31-8

pyrophosphoric acid

N-Palmitoylethanolamine phosphate
84552-09-0

N-Palmitoylethanolamine phosphate

Conditions
ConditionsYield
In methanesulfonic acid83%
succinic acid anhydride
108-30-5

succinic acid anhydride

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

4-oxo-4-(2-palmitamidoethoxy)butanoic acid
117597-84-9

4-oxo-4-(2-palmitamidoethoxy)butanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 18h;83%
In N,N-dimethyl-formamide at 20℃; for 18h;83%
In tetrahydrofuran at 50℃;83%
N-(tert-butyloxycarbonyl)-L-isoleucine
13139-16-7

N-(tert-butyloxycarbonyl)-L-isoleucine

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-isoleucinate

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-isoleucinate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 23℃; for 12h; Steglich Esterification; Inert atmosphere;81%
maleic anhydride
108-31-6

maleic anhydride

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

(E)-4-oxo-4-(2-palmitamidoethoxy)but-2-enoic acid

(E)-4-oxo-4-(2-palmitamidoethoxy)but-2-enoic acid

Conditions
ConditionsYield
In tetrahydrofuran at 50℃;80%
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2564-83-2, 45842-10-2

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-N-(2-((triisopropylsilyl)oxy)ethyl)hexadecanamide

2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-N-(2-((triisopropylsilyl)oxy)ethyl)hexadecanamide

Conditions
ConditionsYield
With pyridine In hexane at 60℃; for 36h; chemoselective reaction;79%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

Boc-Trp-OH
13139-14-5

Boc-Trp-OH

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-tryptophanate

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-L-tryptophanate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 23℃; for 12h; Steglich Esterification; Inert atmosphere;77%
phthalic anhydride
85-44-9

phthalic anhydride

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

2-[(2-palmitamidoethoxy)carbonyl]benzoic acid
31384-20-0

2-[(2-palmitamidoethoxy)carbonyl]benzoic acid

Conditions
ConditionsYield
In tetrahydrofuran at 50℃;75%
In 1,4-dioxane at 40℃; for 5h;
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

N-t-butyloxycarbonyl-D-asparagine
7536-55-2, 142847-17-4, 75647-01-7

N-t-butyloxycarbonyl-D-asparagine

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-D-asparaginate

2-(palmitoylamino)ethyl N-tert-butoxycarbonyl-D-asparaginate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 23℃; for 12h; Steglich Esterification; Inert atmosphere;66%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

N-(2-azidoethyl)palmitamide
1192358-13-6

N-(2-azidoethyl)palmitamide

Conditions
ConditionsYield
With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 2h; Inert atmosphere;66%
indole-3-acetic acid
87-51-4

indole-3-acetic acid

2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

N-palmitoyl-O-(2-(indol-3-yl)-1-oxoethyl)ethanol-2-amine
1363333-30-5

N-palmitoyl-O-(2-(indol-3-yl)-1-oxoethyl)ethanol-2-amine

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In chloroform; acetone at 20℃; for 12h;65.7%
2-(palmitoylamino)ethanol
544-31-0

2-(palmitoylamino)ethanol

2-aminoethyl hexadecanoate
65260-72-2

2-aminoethyl hexadecanoate

Conditions
ConditionsYield
With carbon tetrabromide; triphenylphosphine In acetonitrile for 3.5h;65%
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