Organic Process Research and Development p. 1188 - 1199 (2018)
Update date:2022-08-05
Topics:
Luo, Zhongfeng
Liu, Tingting
Guo, Weijie
Wang, Zijia
Huang, Jingjun
Zhu, Yulin
Zeng, Zhuo
The palladium-catalyzed Suzuki-Miyaura cross-coupling of N-acyl-5,5-dimethylhydantoins with arylboronic acids has been developed via selective amides C-N bond cleavage. The new reagent is commercially available and air-/moisture-stable, and it offers a variety of ketones in good yields through Suzuki coupling under mild conditions (up to 95%).
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Shandong LuZhou Amino Acid Co., Ltd
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