
Tetrahedron Letters p. 2343 - 2346 (1997)
Update date:2022-07-29
Topics:
Lygo, Barry
Crosby, John
Lowdon, Terence R.
Wainwright, Philip G.
An enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine is reported. Key steps involve the use of the Sharpless dihydroxylation protocol to induce asymmetry, and stereodivergent cyclisations of the resulting diol to form the quinuclidine ring.
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