Welcome to LookChem.com Sign In|Join Free
  • or


Post Buying Request

38304-91-5 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Minoxidil FACTORY IN CHINA Minoxidil Loniten CAS 38304-91-5
Cas No: 38304-91-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 200 Metric Ton/Month Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
Anti-hair loss, high quality Minoxidil hair growth
Cas No: 38304-91-5
No Data 1 Kilogram 3 Metric Ton/Month Qingdao Beluga Import and Export Co., LTD Contact Supplier
Cas No: 38304-91-5
USD $ 250.0-260.0 / Kilogram 1 Kilogram 1 Kilogram/Day DB BIOTECH CO., LTD Contact Supplier
High quality minoxidil with best price CAS NO.38304-91-5
Cas No: 38304-91-5
USD $ 30.0-50.0 / Kilogram 1 Kilogram 500 Kilogram/Month Mike(Wuhan) Biotechnology Co.,Ltd Contact Supplier
Top Supplier Topsale Minoxidil 99%
Cas No: 38304-91-5
No Data 25 Kilogram 100000 Kilogram/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
High Quality 99% Minoxidil 38304-91-5 GMP manufacturer
Cas No: 38304-91-5
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Anti hair loss API minoxidil 99% minoxidil powder
Cas No: 38304-91-5
USD $ 200.0-210.0 / Kilogram 1 Kilogram 10 Metric Ton/Day Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
38304-91-5 cas High purity Anti hair loss 99% door to door shipping from Factory Minoxidil
Cas No: 38304-91-5
No Data 1 Kilogram 1-100 Metric Ton/Month Hangzhou Fonlynn Health Technology Co., Ltd. Contact Supplier
99% Minoxidil Powder CAS 38304-91-5 Cosmetics Raw Material For Anti Hair Loss
Cas No: 38304-91-5
USD $ 2.6-3.0 / Gram 10 Gram 10000 Kilogram/Month Shandong Longilat Biotechnology Co., Ltd. Contact Supplier
High Quality Minoxidil For Hair Growth
Cas No: 38304-91-5
USD $ 0.1-0.2 / Kilogram 1 Kilogram 1000 Kilogram/Month Binbo Biological Co., Ltd Contact Supplier

38304-91-5 Usage

an antihypertensive vasodilator medication

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.

Indications and Usage

Minoxidil is a type of oral drug that is clinically used to lower blood pressure, and it is also called Loniten and piperidine diamine. Minoxidil is an antihypertensive drug that is clinically used to treat intractable, primary or renal hypertension. It can also be used to treat severe hypertension that does not respond well to other antihypertensive drugs, but it needs to be used in combination with diuretic drugs to prevent water and sodium retention, and combined use with beta receptor blockers may increase its curative effects and reduce adverse effects. Minoxidil is also used to prevent grease-type alopecia and on livestock.

Mechanisms of Action

Minoxidil is a type of potassium channel opener and can directly relax smooth vascular muscles and has a strong small artery dilating effect. It can reduce peripheral resistance, dilate blood vessels, and lower blood pressure while having no effect on blood volume, thus promoting venous return. In addition, due to reflective regulation and positive frequency effects, it can increase cardiac output and heart rate, but will not cause orthostatic hypotension.

Adverse reactions

Long term use of Minoxidil may have the side effect of increased body hair, such as arm hair. Adverse reactions to oral intake mainly include: weight gain and lower body swelling due to water and sodium retention, heart palpitations and arrhythmia due to reflexive sympathetic nervous excitement, and hirsuitism. Adverse reactions to external use mainly include: skin irritation, red spots in applied areas, itching, and other skin inflammation reactions. Although only a small amount is absorbed, but there is also a slight possibility of causing a recurrence in patients with a history or heart disease. Use with caution if suffering from cerebrovascular disease, non-hypertensive heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases.


Do not use if allergic to Minoxidil or suffering from pheochromocytoma.


Minoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.

Chemical Properties

White Crystalline Solid


Loniten ,Upjohn ,US ,1979


Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels


antihypertensive, antialopecia agent


A selective ATP dependent K+ (Kir6) channel activator


ChEBI: A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.

Manufacturing Process

Barbituric acid is reacted with phosphorus oxychloride then with 2,4,6-trichloropyrimidine and that product with ammonia to give 4-chloro-2,6-diaminopyritnidine.A 30 g (0.15 mol) quantity of 4-chloro-2,6-diaminopyrimidine is dissolved in600 ml of hot 3A alcohol, the solution cooled to 0°C to 10°C and 41.8 g (0.24mol) of m-chloroperbenzoic acid is added. The mixture is held at 0°C to 10°Cfor 4 hours and filtered. The solid is shaken for 2 hours in 0.24 mol of 10%sodium hydroxide and filtered. The solid is washed with water and dried toyield 193 g of crude product. This product is extracted for 1 hour with 900 mlof boiling acetonitrile to yield 14.8 g (44.7% yield) of 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine, melting point 193°C.A mixture of 3.0 g (0.019 mol) of 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine and 35 ml of piperidine is refluxed for 1.5 hours, cooled andfiltered. The solid is shaken for 20 minutes in a solution of 0.8 g of sodiumhydroxide in 30 ml of water and filtered. The solid is washed with water andextracted with 800 ml of boiling acetonitrile and filtered to yield 3.5 g (89%)yield of 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine, meltingpoint 248°C, decomposition at 259°C to 261°C.

Brand name

Loniten (Pharmacia & Upjohn); Rogaine (Pharmacia & Upjohn); Minodyl (Quantum Pharmics).

Therapeutic Function


General Description

Minoxidil, 2,4-diamino-6-piperidinopyrimidine-3-oxide . It is converted to minoxidil sulfate in the liver bya sulfotransferase enzyme.The antihypertensive properties of minoxidil are similarto those of hydralazine hydrochloride, in that minoxidil candecrease arteriolar vascular resistance. Minoxidil exerts itsvasodilatory action by a direct effect on arteriolar smoothmuscle and appears to have no effect on the CNS or on theadrenergic nervous system in animals. The serum half-lifeis 4.5 hours, and the antihypertensive effect may last up to24 hours.

Biological Activity

Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.

Biochem/physiol Actions

Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Mechanism of action

Potassium channel openers are drugs that activate (i.e., open) ATP-sensitive K+ channels in the VSM. By opening these potassium channels, there is increased efflux of potassium ions from the cells, causing hyperpolarization of VSM, which closes the voltage-gated calcium channels and, thereby, decreases intracellular calcium. With less calcium available to combine with calmodulin, there is less activation of MLCK and phosphorylation of myosin light chains. This leads to relaxation and vasodilation. Because small arteries and arterioles normally have a high degree of smooth muscle tone, these drugs are particularly effective in dilating these resistance vessels, decreasing systemic vascular resistance, and lowering arterial pressure. The fall in arterial pressure leads to reflex cardiac stimulation (baroreceptor-mediated tachycardia). Minoxidil, as its active metabolite minoxidil O-sulfate, prolongs the opening of the potassium channel, sustaining greater vasodilation on arterioles than on veins. The drug decreases blood pressure in both the supine and standing positions, and there is no orthostatic hypotension. Associated with the decrease in peripheral resistance and blood pressure is a reflex response that is accompanied by increased heart rate, cardiac output, and stroke volume, which can be attenuated by the coadministration of a β-blocker. Along with this decrease in peripheral resistance is increased plasma renin activity and sodium and water retention, which can result in expansion of fluid volume, edema, and congestive heart failure. The sodium- and water-retaining effects of minoxidil can be reversed by coadministration of a diuretic. When minoxidil is used in conjunction with a β-adrenergic blocker, pulmonary artery pressure remains essentially unchanged.


Minoxidil is absorbed from the GI tract and is metabolized to its active sulfate metabolite. Plasma concentrations for minoxidil sulfate peak within 1 hour and then decline rapidly. Following an oral dose of minoxidil, its hypotensive effect begins in 30 minutes, is maximal in 2 to 8 hours, and persists for approximately 2 to 5 days. The delayed onset of the hypotensive effect for minoxidil is attributed to its metabolism to its active metabolite. The drug is not bound to plasma proteins. The major metabolite for minoxidil is its N-O-glucuronide, which unlike the sulfate metabolite is inactive as a hypotensive agent. Approximately 10 to 20% of an oral dose of minoxidil is metabolized to its active metabolite, minoxidil O-sulfate, and approximately 20% of minoxidil is excreted unchanged.

Clinical Use

Minoxidil is used for severe hypertension that is difficultto control with other antihypertensive agents. The drug hassome of the characteristic side effects of direct vasodilatorydrugs. It causes sodium and water retention and may requirecoadministration of a diuretic. Minoxidil also causes reflextachycardia, which can be controlled by use of a -adrenergicblocking agent.Minoxidil topical solution is used to treat alopecia androgenitica(male-pattern baldness). Although the mechanismis not clearly understood, topical minoxidil is believed to increasecutaneous blood flow, which may stimulate hairgrowth. The stimulation of hair growth is attributed to vasodilationin the vicinity of application of the drug, resultingin better nourishment of the local hair follicles.

Side effects

Adverse reactions include local irritation and contact dermatitis. If the treatment is discontinued, clinical regression occurs within 3 months to the state of hair thinning that would have occurred had the treatment not been started. Twice-daily treatment is more efficacious than once-daily application. Women who use the5%concentrationmay note the development of facial hair, which is reversible on discontinuation of the medication. The 5% concentration can be more irritating than the 2% solution.

Chemical Synthesis

Minoxidil, 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine (22.8.5), is synthesized from barbituric acid, the reaction of which with phosphorous oxychloride gives 2,4,6-trichloropyrimidine (22.8.1). Upon reaction with ammonium, this turns into 2,4-diamino-6-chloropyrimidine (22.8.2). Next, the resulting 2,4-diamino-6- chloropyrimidine (22.8.2) undergoes reaction with 2,4-dichlorophenol in the presence of potassium hydroxide, giving 2,4-diamino-6-(2,4-dichlorophenoxy)-pyrimidine (22.8.3). Oxidation of this product with 3-chloroperbenzoic acid gives 2,4-diamino-6-(2,4- dichlorophenoxy)pyrimidine-3-oxide (22.8.4), the 2,4-dichlorophenoxyl group of which is replaced with a piperidine group at high temperature, giving minoxidil (22.8.5).

Drug interactions

When minoxidil is administered with diuretics or other hypotensive drugs, the hypotensive effect of minoxidil increases, and concurrent use may cause profound orthostatic hypotensive effects.


Extensively metabolised by the liver. It requires sulphation to become active, but the major metabolite is a glucuronide conjugate. Excreted mainly in the urine in the form of metabolites. Minoxidil and its metabolites are dialysable, although the pharmacological effect is not reversed.


1) Meisheri et al. (1988), Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability; J. Pharmacol. Exp. Ther., 245 7 2) Messenger and Rundegren (2004) Minoxidil:mechanisms of action on hair growth; Br. J. Dermatol., 150 186

38304-91-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (M1389)  Minoxidil  >98.0%(HPLC)(T) 38304-91-5 1g 495.00CNY Detail
TCI America (M1389)  Minoxidil  >98.0%(HPLC)(T) 38304-91-5 5g 1,130.00CNY Detail
Sigma-Aldrich (M2300000)  Minoxidil  European Pharmacopoeia (EP) Reference Standard 38304-91-5 M2300000 1,880.19CNY Detail
Sigma-Aldrich (Y0001432)  Minoxidil for system suitability  European Pharmacopoeia (EP) Reference Standard 38304-91-5 Y0001432 1,880.19CNY Detail
USP (1444208)  Minoxidil  United States Pharmacopeia (USP) Reference Standard 38304-91-5 1444208-125MG 3,646.89CNY Detail
Sigma (M4145)  Minoxidil  ≥99% (TLC) 38304-91-5 M4145-25MG 738.27CNY Detail
Sigma (M4145)  Minoxidil  ≥99% (TLC) 38304-91-5 M4145-100MG 1,531.53CNY Detail
Sigma (M4145)  Minoxidil  ≥99% (TLC) 38304-91-5 M4145-250MG 4,413.24CNY Detail
Sigma (M4145)  Minoxidil  ≥99% (TLC) 38304-91-5 M4145-500MG 7,844.85CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name minoxidil

1.2 Other means of identification

Product number -
Other names Regaine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38304-91-5 SDS

38304-91-5Synthetic route

2,6-diamino-4-chloro-pyrimidine N-oxide

2,6-diamino-4-chloro-pyrimidine N-oxide

2,4-diamino-6-piperidinopyrimidine 3-oxide

2,4-diamino-6-piperidinopyrimidine 3-oxide

at 106℃; for 2h;80%


2,6-diamino-4-chloro-pyrimidine N-oxide

2,6-diamino-4-chloro-pyrimidine N-oxide

2,4-diamino-6-piperidinopyrimidine 3-oxide

2,4-diamino-6-piperidinopyrimidine 3-oxide

In dimethyl sulfoxide at 80℃; Rate constant; Thermodynamic data; various temp.; ΔH*, ΔS*;


2,4-diamino-6-piperidinopyrimidine 3-oxide

2,4-diamino-6-piperidinopyrimidine 3-oxide

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 38304-91-5