Synthesis and biological activity of new 2',5'-oligonucleotides

Article abstract of DOI:10.1080/07328319708006186

Some new 2',5'-oligonucleotide trimers containing the antiviral nucleoside ribavirin and the cytokine 6-benzylaminopurine riboside in different position of the oligos have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase, HIV-1 induced syncytia formation and activation of RNase L.

Full text of DOI:10.1080/07328319708006186

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Nucleosides and Nucleotides
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Synthesis and Biological Activity of
New 2′ 5′-Oligonucleotides
Evgeny I. Kvasyuk a , Tamara I. Kulak a , Igor A. Mikhailopulo a ,
Robert J. Suhadolnik b , Earl E. Henderson c , Susan E. Horvath b
, Ming-Xu Guan c & Wolfgang Pfleiderer d
a Institute of Bioorganic Chemistry, Byelorussian Academy of
Sciences , Minsk, 220141, Belarus
b Department of Biochemistry , Fels Institute for Cancer
Research and Molecular Biology, Temple University School of
Medicine , Philadelphia, PA, 19140, USA
c Department of Microbiology and Immunology , Fels Institute
for Cancer Research and Molecular Biology, Temple University
School of Medicine , Philadelphia, PA, 19140, USA
d Fakultät für Chemie , Universität Konstanz , Postfach 5560,
D-78434, Konstanz
Published online: 16 Aug 2006.
To cite this article: Evgeny I. Kvasyuk , Tamara I. Kulak , Igor A. Mikhailopulo , Robert J.
Suhadolnik , Earl E. Henderson , Susan E. Horvath , Ming-Xu Guan & Wolfgang Pfleiderer (1997)
Synthesis and Biological Activity of New 2′ 5′-Oligonucleotides, Nucleosides and Nucleotides,
16:7-9, 1351-1354, DOI: 10.1080/07328319708006186
To link to this article: http://dx.doi.org/10.1080/07328319708006186
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