Synthesis of (4S)-hydroxymethyl-(2R)-(2-propyl)-butyrolactone: A quest for a practical route to an important hydroxyethylene isostere chiron

DOI: 10.1016/S0040-4020(97)00298-6

Source and publish data:

Tetrahedron p. 6281 - 6294 (1997)

Update date:2022-09-26

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Authors:

Hanessian, Stephen

Abad-Grillo, Teresa

McNaughton-Smith, Grant

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Article abstract of DOI:10.1016/S0040-4020(97)00298-6

Several approaches for the stereocontrolled introduction of a 2-propyl group into (4S)-hydroxymethyl-1,4-butyrolactone via cholate chemistry were investigated. A practical synthesis of the (2R)- and (2S)-isomers was developed.

Full text of DOI:10.1016/S0040-4020(97)00298-6

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