Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1-R-(pyridyl)ethyl ether terminus

DOI: 10.1016/S0960-894X(98)00568-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3081 - 3086 (1998)

Update date:2022-07-31

Topics:

Authors:

Kuo, Michelle S.

Bock, Mark G.

Freidinger, Roger M.

Guidotti, Maribeth T.

Lis, Edward V.

Pawluczyk, Joseph M.

Perlow, Debra S.

Pettibone, Douglas J.

Quigley, Amy G.

Reiss, Duane R.

Williams, Peter D.

Woyden, Carla J.

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Article abstract of DOI:10.1016/S0960-894X(98)00568-X

Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group.

Full text of DOI:10.1016/S0960-894X(98)00568-X

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Product name:Benzoic acid, 5-fluoro-2-methoxy-4-[1-(4-pyridinyl)ethoxy]-, (R)-

Cas No:194152-23-3

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