An enantioselective route to trans-2,6-disubstituted piperidines

DOI: 10.1016/S0040-4020(97)00377-3

Source and publish data:

Tetrahedron p. 11203 - 11210 (1997)

Update date:2022-09-26

Topics:

Authors:

Chackalamannil, Samuel

Wang, Yuguang

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Article abstract of DOI:10.1016/S0040-4020(97)00377-3

The synthesis of (S)-2-methyl tetrahydropyridine-N-oxide (4), a key intermediate for the enantioselective construction of trans-2,6-disubstituted piperidines via [3+2] nitrone cycloaddition reaction, is described. Nitrone 4 was elaborated to the fire ant venom alkaloid (+)-solenopsin-A (2) via intermediate 14.

Full text of DOI:10.1016/S0040-4020(97)00377-3

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