A Concise Synthesis of Optically Active 2- Bromotryptophan Amino Acids Present in Konbamide and Jaspamide Via A Regiospecific Bromination Procedure

Article abstract of DOI:10.1016/0040-4039(95)01956-I

A highly stereoselective synthesis of optically active 2-bromo-5-hydroxytryptophan 1a and important derivatives 1b and 1c as well as their 2-bromotryptophan analogs was achieved in three steps from 2-bromo-3-bromomethylindoles 3a and 3b, respectively.