A convenient synthesis of 5-hydroxy-2'-deoxycytidine phosphoramidite and its incorporation into oligonucleotides

DOI: 10.1016/S0040-4039(97)10024-7

Source and publish data:

Tetrahedron Letters p. 7531 - 7534 (1997)

Update date:2022-07-31

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Authors:

Romieu, Anthony

Gasparutto, Didier

Molko, Didier

Cadet, Jean

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Article abstract of DOI:10.1016/S0040-4039(97)10024-7

Oligonucleotides containing 5-hydroxy-2'-deoxycytidine (2) have been synthesized using the phosphoramidite chemistry. The presence and the integrity of the modified nucleoside in the synthetic oligomers were confirmed by electrospray mass spectrometry and chromatographic analysis of enzymatic digestion coupled with W detection.

Full text of DOI:10.1016/S0040-4039(97)10024-7

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