A convenient synthesis of 5-hydroxy-2'-deoxycytidine phosphoramidite and its incorporation into oligonucleotides

DOI: 10.1016/S0040-4039(97)10024-7

Source and publish data:

Tetrahedron Letters p. 7531 - 7534 (1997)

Update date:2022-07-31

Topics:

Authors:

Romieu, Anthony

Gasparutto, Didier

Molko, Didier

Cadet, Jean

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)10024-7

Oligonucleotides containing 5-hydroxy-2'-deoxycytidine (2) have been synthesized using the phosphoramidite chemistry. The presence and the integrity of the modified nucleoside in the synthetic oligomers were confirmed by electrospray mass spectrometry and chromatographic analysis of enzymatic digestion coupled with W detection.

Full text of DOI:10.1016/S0040-4039(97)10024-7

Products guided by the article

Product name:5-HYDROXY-DC CEP

Cas No:197579-70-7

R&D Labs maybe for 197579-70-7

Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Shanghai Send Pharmaceutical Technology Co., Ltd.

website:http://www.shsendpharma.com

Contact:021-58088081, +8613585868794

Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
CHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD

website:http://www.fengrunhuagong.com

Contact:+86-536-7869976

Address:Changyi Coastal Economic Development Zone
suzhou chukai pharmateach co,.ltd

Contact:86-512-88812511

Address:Building 3, Wujiang Scientific Innovation Park, 2358 Changan Rd, Wujiang 215200, Jiangsu Province, P. R. China
Shenzhen Sungening Medicine Co., Ltd

Contact:+86-871-65110906

Address:Room702, Building 2, 365 Dianchi Road, Kunming, Yunnan Province, P.R. China

Relevant to this article

Heterocyclic systems containing tin(IV) - XIII [1]. Possible ceasing or inversion of the structural trans influence during the course of a bimolecular nucleophilic attack of a donor group in a series of Sn^IV rings

Doi:10.1016/S0277-5387(97)00180-0
(1997)
Doi:10.1039/j39680002502
(1968)
Regio- and diastereoselective synthesis of cyclic amino esters

Doi:10.1016/S0040-4039(00)02217-6
(2001)
Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK and F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the α₂-adrenoceptor

Doi:10.1021/jm960235e
(1997)
Generation of 1,2-bisketenes from cyclobutene-1,2-diones by flash photolysis and ring closure kinetics

Doi:10.1021/ja9722685
(1997)
DNA-directed synthesis of aniline and 4-aminobiphenyl oligomers: Programmed transfer of sequence information to a conjoined polymer nanowire

Doi:10.1021/ja0726106
(2008)

Article Doi