Synthesis and antibacterial activity of 1-β-methylcarbapenem having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety

Article abstract of DOI:10.1002/ardp.19963291004

The synthesis of new series of 1-β-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram negative bacteria are reported and the effect of the substituent on the bicyclic ring was investigated and was in agreement with findings from our previous studies.