The asymmetric Michael reaction involving chiral imines: Use of acrylonitrile as acceptor and subsequent functionalization of the adducts

DOI: 10.1016/0957-4166(94)80071-5

Source and publish data:

Tetrahedron Asymmetry p. 1645 - 1648 (1994)

Update date:2022-08-02

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Authors:

Desmaele

Zouhiri Zouhiri

D'Angelo

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Article abstract of DOI:10.1016/0957-4166(94)80071-5

Condensation of chiral imines 1 and acrylonitrile led to adduct (R)-6 with an ee ≥ 95%. This adduct has then been converted into chiral synthons 9, 11, 12 and 17.

Full text of DOI:10.1016/0957-4166(94)80071-5

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