Synthesis of Pyrido[2,3-d]pyrimidines from Aminopyrimidinecarbaldehydes

Article abstract of DOI:10.1002/jhet.5570350226

2-Metboxy-4-amino-5-pyrimidinecarbaldebyde (2a) as well as its 6-methyl 2b and 6-phenyl derivatives 2c were prepared by reduction of the corresponding aminopyrimidinecarbonitriles 1. Catalytic hydrogenation of 1a, 1b gives 5-hydroxymethylpyrimidines 3a, 3