Bioorganic and Medicinal Chemistry Letters p. 1953 - 1956 (1999)
Update date:2022-08-04
Topics:
Anderson, Benjamin A.
Harn, Nancy K.
Hansen, Marvin M.
Harkness, Allen R.
Lodge, David
Leander, J. David
A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists.
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