Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazepine AMPA antagonists

DOI: 10.1016/S0960-894X(99)00315-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1953 - 1956 (1999)

Update date:2022-08-04

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Authors:

Anderson, Benjamin A.

Harn, Nancy K.

Hansen, Marvin M.

Harkness, Allen R.

Lodge, David

Leander, J. David

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Article abstract of DOI:10.1016/S0960-894X(99)00315-7

A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists.

Full text of DOI:10.1016/S0960-894X(99)00315-7

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