Studies in marine macrolide synthesis: Construction of a 24-membered macrocyclic intermediate for aplyronine A

Article abstract of DOI:10.1016/S0040-4039(98)01192-7

The C₁-C₂₇ macrolide 2, which contains 11 stereocentres and 4 double bonds, was constructed by an efficient 3-component coupling followed by a macrolactonisation/isomerisation sequence. Key steps were the alkylation of the dianion of