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| CAS No.: | 1185-53-1 |
|---|---|
| Name: | 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | C4H12ClNO3 |
| Molecular Weight: | 157.597 |
| Synonyms: | Tris(Hydroxymethyl)aminomethane hydrochloride [TRIS·HCL];Tris HCl;Tris-HCL;1,3-Propanediol,2-amino-2-(hydroxymethyl)-, hydrochloride (8CI,9CI);2-Amino-2-(hydroxymethyl)-1,3-propanediolhydrochloride;T 6666;Tri(hydroxymethyl)aminomethane hydrochloride;Trischloride;Tris(hydroxymethyl)aminomethane hydrochloride;Trizma hydrochloride; |
| EINECS: | 214-684-5 |
| Density: | 1.05g/mLat 20°C |
| Melting Point: | 150-152 ºC |
| Boiling Point: | 357 ºC at 760 mmHg |
| Flash Point: | 169.7 ºC |
| Solubility: | soluble in water |
| Appearance: | White crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 86.71000 |
| LogP: | -0.83690 |
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- 1185-53-1
tris hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol for 1h; Heating; | 80% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 20℃; for 3h; |
- 40018-26-6
1,4-dithiane-2,5-diol
- 1185-53-1
tris hydrochloride
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid In toluene for 3h; Reflux; | 97% |
| Conditions | Yield |
|---|---|
| Stage #1: cycloxexanone dimethyl ketal; tris hydrochloride With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 17h; Stage #2: With triethylamine In ethyl acetate | 94% |
- 1125-88-8
benzaldehyde dimethyl acetal
- 1185-53-1
tris hydrochloride
- 51430-74-1
5-amino-5-hydroxymethyl-2-phenyl-1,3-dioxane
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid; triethylamine for 12h; Ambient temperature; | 90% |
| Conditions | Yield |
|---|---|
| Stage #1: 3H3N*3H(1+)*[CrMo6O18(OH)6](3-); 2-amino-2-hydroxymethyl-1,3-propanediol In water at 130℃; for 13h; Stage #2: tris hydrochloride In water at 20℃; for 0.166667h; | 90% |
- 1185-53-1
tris hydrochloride
- 77-76-9
2,2-dimethoxy-propane
- 53104-32-8
(5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid; N,N-dimethyl-formamide for 12h; Ambient temperature; | 86% |
| Stage #1: tris hydrochloride; 2,2-dimethoxy-propane With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 60h; Stage #2: With triethylamine In methanol; N,N-dimethyl-formamide Sonication; Stage #3: With triethylamine In methanol; ethyl acetate; N,N-dimethyl-formamide at 20℃; for 0.166667h; | 86% |
| Stage #1: tris hydrochloride; 2,2-dimethoxy-propane; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 18h; Stage #2: With triethylamine In ethyl acetate for 0.5h; | 85% |
- 1185-53-1
tris hydrochloride
- 66-99-9
β-naphthaldehyde
- 253437-24-0
5-amino-5-hydroxymethyl-2-(2-naphthyl)-1,3-dioxane
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid In benzene for 12h; Condensation; Heating; | 85% |
- 1185-53-1
tris hydrochloride
- 66-77-3
1-naphthaldehyde
- 253437-27-3
5-amino-5-hydroxymethyl-2-(1-naphthyl)-1,3-dioxane
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid In benzene for 12h; Condensation; Heating; | 82% |
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 19h; | 80% |
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Chemistry
Molecular Structure:
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Molecular Formula: C4H12ClNO3
Molecular Weight: 157.596
IUPAC Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride
Synonyms of Tris hydrochloride (CAS NO.1185-53-1): 2-Amino-2-hydroxymethyl-1,3-propanediol hydrochloride ; EINECS 214-684-5 ; Tris chloride ; Tris hydrochloride buffer ; Tris(hydroxymethyl)aminomethane hydrochloride ; Trizma hydrochloride ; Tromethamine HCl ; Tris(hydroxymethyl)aminomethanehydrochloride ; UNII-383V75M34E ; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride ; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1)
CAS NO: 1185-53-1
Product Categories: Buffer
Melting Point: 150-152 °C
H bond acceptors: 4
H bond donors: 5
Freely Rotating Bonds: 7
Polar Surface Area: 30.93 Å2
Flash Point: 169.7 °C
Enthalpy of Vaporization: 69.73 kJ/mol
Boiling Point: 357 °C at 760 mmHg
Vapour Pressure: 1.57E-06 mmHg at 25°C
Uses
Tris hydrochloride (CAS NO.1185-53-1) is used as a organic intermediate.
Safety Profile
Safety Information of Tris hydrochloride (CAS NO.1185-53-1):
Hazard Codes:Xi 
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
WGK Germany:3
F:3
HS Code:29221980
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