Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling

Article abstract of DOI:10.1016/S0960-894X(99)00313-3

Rational drug design utilizing a receptor homology model of the human muscarinic M₁ receptor led to the discovery of the highly potent (K(i) = 2 nM), efficacious, and in vivo functionally-selective M₁ agonist, WAY- 132983.