Bioorganic and Medicinal Chemistry Letters p. 1895 - 1900 (1999)
Update date:2022-08-03
Topics:
Sabb, Annmarie L.
Morris Husbands
Tokolics, Joseph
Stein, Reinhardt P.
Tasse, Rene P.
Boast, Carl A.
Moyer, John A.
Abou-Gharbia, Magid
Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (K(i) = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY- 132983.
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