Intramolecular synthesis of N thiophosphonylated thiopeptides. The case of thiosarcosine

DOI: 10.1016/S0040-4039(98)01982-0

Source and publish data:

Tetrahedron Letters p. 8841 - 8844 (1998)

Update date:2022-09-26

Topics:

Authors:

Alibert, Sonia

Crestia, Dominique

Dujols, Frederic

Mulliez, Michel

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Article abstract of DOI:10.1016/S0040-4039(98)01982-0

A new, three-step, method is proposed for the synthesis of thiopeptides. Each step is verified starting from a sarcosylthiophosphondiamide model and using alcohols or water for the last one. With amines a different regioselective attack on the thiocarbonyl, instead of on the thiophosphoryl with alcohols, is observed.

Full text of DOI:10.1016/S0040-4039(98)01982-0

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