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Acetyl tributyl citrate 77-90-7 supplier in China
Cas No: 77-90-7
USD $ 11.0-22.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
China hot selling whole sell Acetyl tributyl citrate 77-90-7 global trader
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USD $ 550.0-550.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Acetyl Tributyl Citrate(Reach) supplier in China
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No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Acetyl tributyl citrate
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USD $ 12.0-12.0 / Metric Ton 1 Metric Ton 5000 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Acetyl tributyl citrate 77-90-7 supplier in China
Cas No: 77-90-7
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Acetyl tributyl citrate
Cas No: 77-90-7
No Data 1 Kilogram 3000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Acetyltributyl Citrate (500 mg)
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No Data 1 Kilogram 1 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Tributyl O-acetylcitrate
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No Data 1 1 Ality Chemical Corporation Contact Supplier
Acetyl tributyl citrate(ATBC)
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No Data 1 Metric Ton 100 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier
High Quality 99% Acetyl tributyl citrate 77-90-7 ISO Producer
Cas No: 77-90-7
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

77-90-7 Usage

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

Uses

plasticizer flavoring agent

Definition

Aqueous-based pharmaceutical coat- ings.

Preparation

From citric acid via the tributyl ester followed by acetylation.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

General Description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful. LD50 (cat, oral): >50 mL/kg LD50 (mouse, IP): >4 g/kg LD50 (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

Uses

plasticizer flavoring agent

Definition

Aqueous-based pharmaceutical coat- ings.

Preparation

From citric acid via the tributyl ester followed by acetylation.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

General Description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful. LD50 (cat, oral): >50 mL/kg LD50 (mouse, IP): >4 g/kg LD50 (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.
InChI:InChI=1/C12H18O8/c1-3-4-5-19-11(17)12(18,6-9(14)15)7-10(16)20-8(2)13/h18H,3-7H2,1-2H3,(H,14,15)/p-1

77-90-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (PHR1156)    pharmaceutical secondary standard; traceable to USP and PhEur 77-90-7 PHR1156-1G 732.19CNY Detail
Sigma-Aldrich (Y0001055)  Tributyl acetylcitrate  European Pharmacopoeia (EP) Reference Standard 77-90-7 Y0001055 1,880.19CNY Detail
USP (1009901)  Acetyltributyl citrate  United States Pharmacopeia (USP) Reference Standard 77-90-7 1009901-500MG 4,662.45CNY Detail

77-90-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Tributyl 2-acetylcitrate

1.2 Other means of identification

Product number -
Other names 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77-90-7 SDS

77-90-7Synthetic route

vinyl acetate
108-05-4

vinyl acetate

Citroflex-4
77-94-1

Citroflex-4

acetyltributyl citrate
77-90-7

acetyltributyl citrate

Conditions
ConditionsYield
With potassium tert-butylate; 1-ethyl-3-methylimidazolium tetrafluoroborate In tetrahydrofuran at 70℃; for 12h; Reagent/catalyst; Solvent; Time; Temperature; Concentration; Inert atmosphere;81%
Citroflex-4
77-94-1

Citroflex-4

acetic anhydride
108-24-7

acetic anhydride

acetyltributyl citrate
77-90-7

acetyltributyl citrate

Conditions
ConditionsYield
dmap at 100℃; for 24h;93%
With 1-butyl-3-methylimidazolium 4-methylbenzenenesulfonate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 50℃; for 8h;19%
at 70 - 80℃; Concentration;
Citroflex-4
77-94-1

Citroflex-4

acetic acid
64-19-7

acetic acid

acetyltributyl citrate
77-90-7

acetyltributyl citrate

Conditions
ConditionsYield
[Mes2NH2](+)[O3SC6F5](-) In n-heptane at 115℃; for 48h;31%

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