Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

77-90-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

77-90-7 Usage


Acetyl tributyl citrate is a versatile organic compound that serves as a high-boiling plasticizer and solvent. It is commonly used in various industries due to its ability to dissolve a wide range of substances and its compatibility with many polymers.


Used in Pharmaceutical Industry:
Acetyl tributyl citrate is used as a secondary standard for several analytical applications, including pharmaceutical release testing, method development for qualitative and quantitative analyses, and calibration requirements.
Used in Topical Pharmaceutical Formulations:
In the pharmaceutical industry, Acetyl tributyl citrate is used as an anesthetic surfactant ester in topical formulations, providing a numbing effect and enhancing the absorption of other active ingredients.
Used in Food and Beverage Industry:
Acetyl tributyl citrate is used as a plasticizer and flavoring agent in the food and beverage industry, helping to improve the texture, taste, and stability of various products.
Used in Plastics Industry:
Acetyl tributyl citrate is used as a high-boiling plasticizer in the plastics industry, providing flexibility and workability to a wide range of polymers, including PVC, cellulose acetate, and polyvinyl butyral.


From citric acid via the tributyl ester followed by acetylation.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750


and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful. LD50 (cat, oral): >50 mL/kg LD50 (mouse, IP): >4 g/kg LD50 (rat, oral): >31.5 g/kg


The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.


Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.


Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Check Digit Verification of cas no

The CAS Registry Mumber 77-90-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 77-90:
67 % 10 = 7
So 77-90-7 is a valid CAS Registry Number.

77-90-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma-Aldrich

  • (PHR1156)    pharmaceutical secondary standard; traceable to USP and PhEur

  • 77-90-7

  • PHR1156-1G

  • 732.19CNY

  • Detail
  • Sigma-Aldrich

  • (Y0001055)  Tributyl acetylcitrate  European Pharmacopoeia (EP) Reference Standard

  • 77-90-7

  • Y0001055

  • 1,880.19CNY

  • Detail
  • USP

  • (1009901)  Acetyltributyl citrate  United States Pharmacopeia (USP) Reference Standard

  • 77-90-7

  • 1009901-500MG

  • 4,662.45CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Tributyl 2-acetylcitrate

1.2 Other means of identification

Product number -
Other names 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77-90-7 SDS

77-90-7Synthetic route

vinyl acetate

vinyl acetate



acetyltributyl citrate

acetyltributyl citrate

With potassium tert-butylate; 1-ethyl-3-methylimidazolium tetrafluoroborate In tetrahydrofuran at 70℃; for 12h; Reagent/catalyst; Solvent; Time; Temperature; Concentration; Inert atmosphere;81%


acetic anhydride

acetic anhydride

acetyltributyl citrate

acetyltributyl citrate

dmap at 100℃; for 24h;93%
With 1-butyl-3-methylimidazolium 4-methylbenzenenesulfonate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 50℃; for 8h;19%
at 70 - 80℃; Concentration;


acetic acid

acetic acid

acetyltributyl citrate

acetyltributyl citrate

[Mes2NH2](+)[O3SC6F5](-) In n-heptane at 115℃; for 48h;31%

77-90-7Downstream Products

77-90-7Relevant articles and documents

N-Heterocyclic carbene-catalyzed synthesis of acetyltributylcitrate via a transesterification reaction

He, Lin,Guo, Hao,Ma, Xiao-Wei,Zhang, Jie,Gu, Cheng-Zhi,Wang, Wei,Dai, Bin

, p. 215 - 217 (2014)

A new methodology for the synthesis of a green plasticizer acetyltributylcitrate through a transesterification reaction was developed. Under the catalysis of alkyl-substituted imidazol-type N-heterocyclic carbenes, tributyl citrate can react with vinyl acetate smoothly to give ATBC in high yield.

An imidazolium tosylate salt as efficient and recyclable catalyst for acetylation in an ionic liquid

Liu, Ye,Liu, Lu,Lu, Yong,Cai, Yue-Qin

experimental part, p. 633 - 638 (2009/08/07)

A novel non-metallic salt, 1-butyl-3-methylimidazolium tosylate ([bmim][OTs]) dissolved in the ambient temperature ionic liquid of 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]), was found to be the efficient catalyst for acetylation with the advantages of good recyclability, avoidance of metal contamination, mild reaction conditions, and wide availability for substrates (alcohols, phenols, and amines), could completely replace organic bases, metal Lewis acids, or metallic triflates to fulfill acetylation by a nucleophilic catalytic mechanism, which was supported by 13C NMR analysis.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 77-90-7