Total synthesis of (-)- and (±)-frontalin via ring-closing metathesis

Article abstract of DOI:10.1016/S0040-4039(98)02677-X

Racemic and enantiopure targets containing the 6,8-dioxabicyclo [3.2.1]octane skeleton, can be conveniently synthesized from monocyclic diene precursors using an intramolecular ruthenium-catalyzed ring-closing metathesis reaction as the key step.