Synthesis and antimicrobial evaluation of several new pyridine, thienopyridine and pyridothienopyrazole derivatives

Article abstract of DOI:10.1080/10426509908037022

The reaction of thiocyanoacetamide (1) with α,β-unsaturated ketones 2a,b resulted in the formation of the corresponding newly synthesized 1 (H)pyridinethione derivatives 3a,b. Compounds 3a,b were used as synthons for the preparation of 2-S-alkyl-, 2-S-aryl-, 2-S-acetamidopyridine, thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives via a wide range of reactions with different reagents. The antimicrobial activity of some of the newly synthesized compounds was tested. Compounds 3a, 11a, 15a, and 19a,b were found to be the most active ones.

Full text of DOI:10.1080/10426509908037022

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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SYNTHESIS AND ANTIMICROBIAL
EVALUATION OF SEVERAL NEW
PYRIDINE, THIENOPYRIDINE
AND PYRIDOTHIENOPYRAZOLE
DERIVATIVES
Fawzy A. Attaby a , M. A. A. Elneairy a & M. S.
Elsayed a
a Chemistry Department, Faculty Of Science, Cairo
University, Giza, Egypt
Version of record first published: 24 Sep 2006.
To cite this article: Fawzy A. Attaby, M. A. A. Elneairy & M. S. Elsayed (1999):
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SEVERAL NEW PYRIDINE,
THIENOPYRIDINE AND PYRIDOTHIENOPYRAZOLE DERIVATIVES, Phosphorus, Sulfur, and
Silicon and the Related Elements, 149:1, 49-64
To link to this article: http://dx.doi.org/10.1080/10426509908037022
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