616204-22-9 Usage
Description
Argireline, also known as Acetyl hexapeptide-3, is a synthetic anti-wrinkle peptide derived from the peptide substrate of Botulinum toxin, commonly known as Botox. It is made up of chains of amino acids that can influence how our cells function, such as relaxing facial muscles. Clinical studies have shown that Argireline can effectively reduce the depth of existing wrinkles, making it a popular ingredient in products marketed as having a topical-Botox or "wrinkle-erasing" effect.
Uses
Used in Cosmetics and Skincare Industry:
Argireline is used as an anti-aging ingredient for its ability to reduce the depth of existing wrinkles and prevent the formation of new ones. It works by inhibiting muscle movement in the face, which helps in achieving anti-aging results similar to those of Botox treatments. As a result, Argireline cream is sometimes referred to as "Botox in a jar."
Used in Topical-Botox Products:
Argireline is used as a key component in products that claim to have a topical-Botox or "wrinkle-erasing" effect. Its effectiveness in reducing wrinkles and preventing their formation makes it a highly sought-after ingredient in the cosmetics and skincare industry, offering a non-invasive alternative to traditional Botox treatments.
benefits
Acetyl Hexapeptide-8 is effectivly reduce various kind of facial wrinkles;Replenish the collagen and polysaccharide, repairthe skin.Winkey patented productin China.It is recommended dosage is 3~10%.
Clinical claims and research
Argireline is a synthetic oligopeptide that emulates the sequence of SNAP-25, a type of SNARE. It has significant skin permeation, interferes with the SNARE ternary complex, and has demonstrated interference with catecholamine release from chromaffin cells. Topical use of 10% argireline resulted in a reduced depth and roughness of periorbital wrinkles in 10 healthy women. One study on 14 volunteers showed that 5% argireline reduced periorbital wrinkles by 32% in 28 days. Most recently, argireline’s efficacy has been measured in 60 Chinese women from a randomized control trial. Its total efficacy was 48.9% compared to 0% in the placebo group, and resulted in significantly decreased wrinkle roughness.
Check Digit Verification of cas no
The CAS Registry Mumber 616204-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,6,2,0 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 616204-22:
(8*6)+(7*1)+(6*6)+(5*2)+(4*0)+(3*4)+(2*2)+(1*2)=119
119 % 10 = 9
So 616204-22-9 is a valid CAS Registry Number.
InChI:InChI=1/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1
616204-22-9Relevant articles and documents
Sustainable Peptide Synthesis Enabled by a Transient Protecting Group
Avrutina, Olga,Knauer, Sascha,Koch, Niklas,Kolmar, Harald,Meusinger, Reinhard,Uth, Christina
supporting information, p. 12984 - 12990 (2020/06/01)
The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly from protected building blocks, and switching to water as a reaction medium remains a major hurdle in peptide chemistry. We report an aqueous solid-phase peptide synthesis strategy that is based on a water-compatible 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting group. This approach enables peptide assembly under aqueous conditions, real-time monitoring of building block coupling, and efficient postsynthetic purification. The procedure for the synthesis of all natural and several non-natural Smoc-protected amino acids is described, as well as the assembly of 22 peptide sequences and the fundamental issues of SPPS, including the protecting group strategy, coupling and cleavage efficiency, stability under aqueous conditions, and crucial side reactions.
