The efficient stereoselective synthesis of (2S,3R,4S,5S,6S,11E)3-amino- 6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec-11-enoic acid (AMMTD), a component of microsclerodermins of marine sponge origin, as its protected form

Article abstract of DOI:10.1016/S0040-4039(99)00411-6

The title acid, a component of microsclerodermins of marine sponge origin having five consecutive stereogenie centers, was efficiently synthesized as its protected form 1 from the alcohol 5 utilizing the stereoselective addition of anisole to the acetylenic triple bond and the anti-aldol reaction as key steps.